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US 6,306,648 B1Granted
Cyclin-C variants, and diagnostic and therapeutic uses thereof
AssigneeSt. Jude Children's Research Hospital
InventorsJill M. Lahti, Vincent J. Kidd
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AssigneeSt. Jude Children's Research Hospital
InventorsJill M. Lahti, Vincent J. Kidd
Estimating the term…
The present invention includes alternatively and partially spliced cyclin C mRNAs, recombinant DNA and the truncated protein (a truncated cyclin C) they encode. The alternatively spliced mRNAs result from an insertion of unique exons containing premature termination codons. The partially spliced mRNAs result from an insertion of additional coding sequence derived from exons. One aspect of the present invention is the demonstration that at least one of the alternatively spliced cyclin C mRNAs is produced in a cell cycle dependent fashion, as is the novel truncated cyclin box protein that it encodes. Truncated cyclin C acts as an endogenously encoded cyclin C inhibitor by negatively regulating cyclin C/cdk8 complex activity, in much the same way as the cyclin dependent protein kinase inhibitors that inhibit the D-type cyclins, cyclin A and cyclin E.
An isolated amino acid polymer corresponding to a peptide or protein that is encoded by an alternatively spliced cyclin C mRNA, wherein said amino acid polymer hinders the formation of an active cyclin C-cdk8 complex.
An antibody for an amino acid polymer corresponding to a peptide or protein that is encoded by an alternatively spliced cyclin C mRNA, wherein said amino acid polymer hinders the formation of an active cyclin C-cdk8 complex;
An isolated nucleic acid that encodes an amino acid polymer corresponding to a peptide or protein that is encoded by an alternatively spliced cyclin C mRNA, wherein said amino acid polymer hinders the formation of an active cyclin C-cdk8 complex.
An isolated nucleic acid that encodes the amino acid polymer comprising the amino acid sequence of SEQ ID NO:3.
An isolated nucleic acid encoding an amino acid polymer having an amino acid sequence of SEQ ID NO:50.
An antibody to an isolated amino acid polymer corresponding to a human cyclin C that does not encode a PEST sequence rich carboxy terminal domain;
Dependencies are inferred from the claim text.