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US 6,306,647 B1Granted
Process for producing and purifying 2′,3′-dideoxynucleosides, and process for producing 2′,3′-dideoxy-2′,3′-didehydronucleosides
AssigneeAjinomoto Co., Inc.
InventorsHiroshi Shiragami, Yasuo Irie, Naohiko Yasuda
Life of this patent
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Abstract
A process for converting uridines to 2′,3′-dideoxy-2′,3′-didehydrouridines by reacting acetic anhydride with a 2′,3′-0-alkoxymethylideneuridine intermediate.
Claims4
A process for obtaining a 2′,3′-dideoxy-2′,3′-didehydronucleoside of formula (VIII):
- wherein B is an unsubstituted or 5-substituted uracil residue bound at its 1-position, and R2 is a hydrogen atom, an acyl group, an aralkyl group, or a silyl group, said process comprising reacting, with an acid anhydride, a nucleoside derivative of formula (VII):
- wherein R1 is an alkyl group having 1 to 12 carbon atoms and B is identical to the uracil residue of formula (VIII).
A process for obtaining a 2′,3′-dideoxy-2′, 3′-didehydronucleoside of formula (VIII):
- wherein B is a non-substituted uracil residue bound at its 1-position, and R2 is a hydrogen atom, an acyl group, an aralkyl group, or a silyl group, said process comprising reacting, with an acid anhydride, a nucleoside derivative of formula (VII):
- wherein R1 is an alkyl group having 1 to 12 carbon atoms and B is identical to the uracil residue of formula (VIII).
Dependencies are inferred from the claim text.