Microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain
AssigneeYungjin Pharmaceutical Ind. Co., Ltd.
InventorsJoo-Kyung Lee, Joo-Woong Park, Dong-Jin Seo, Sang-Choon Lee, Ji-Yoon Kim
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Abstract
The present invention is related to a new microorganism Streptomyces exfoliatus YJ-118 and a method for producing pravastatin sodium by using this microorganism which shows a strong tolerance to ML-236B and a high hydroxylation activity of ML-236B to pravastatin.
Claims4
An isolated Streptomyces exfoliatus YJ-118.
A method for producing pravastatin sodium represented in formula I comprising culturing Streptomyces exfoliatus YJ-118 in the presence of ML-236B represented in formula II-a and formula II-b and allowing the Streptomyces exfoliatus YJ-118 to hydroxylate the ML-236B represented in formula II-a and formula II-b;
Dependencies are inferred from the claim text.