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US 6,306,606 B1Granted
Antisense modulation of MP-1 expression
AssigneesIsis Pharmaceuticals, Inc., University of Virginia
InventorsMichael J. Weber, Jacqueline Wyatt, Lex M. Cowsert
Life of this patent
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of MP-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MP-1. Methods of using these compounds for modulation of MP-1 expression and for treatment of diseases associated with expression of MP-1 are provided.
Claims13
An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 18, 19, 21, 22, 23, 27, 29, 30, 31, 33, 34, 35, 36, 38, 39, 40, 42, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 59, 63, 64, 65, 66, 67, 70, 71, 72, 77, 78, 79, 82, 84, 85, 86, 88, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 117, 118, 121, 123, 124, 125, 126, 127, 128, 129, 130, 131, 133, 134 or 135 which inhibits the expression of MP-1.
Dependencies are inferred from the claim text.