Nucleic acid-coupled colorimetric analyte detectors
AssigneeThe Regents of the University of California
InventorsDeborah H. Charych, Ulrich Jonas
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Abstract
The present invention relates to methods and compositions for the direct detection of analytes and membrane conformational changes through the detection of color changes in biopolymeric materials. In particular, the present invention provide for the direct colorimetric detection of analytes using nucleic acid ligands at surfaces of polydiacetylene liposomes and related molecular layer systems.
Claims23
A composition comprising one or more biopolymeric materials comprising a plurality of polymerized self-assembling lipid monomers and one or more nucleic acid ligands, wherein binding of an analyte to said nucleic acid ligand causes a conformational change in said polymerized self-assembling lipid monomers, resulting in a color change in said biopolymeric materials.
Dependencies are inferred from the claim text.