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US 6,306,439 B1Granted
Expandable pharmaceutical forms
AssigneeBayer Aktiengesellschaft
InventorsGunther Penners, Klemens Lustig, Jörg Petersen-von Gehr
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Abstract
The present invention relates to administration forms having a relatively long gastric residence time, in the preparation of which mixtures of polymers containing lactam groups and polymers containing carboxyl groups are used, and which are distinguished both by marked swelling properties and by high dimensional stability in the swollen state.
Claims4
A pharmacologically active composition in a physical form imparting a prolonged gastric residence time, said physical form being selected from the group consisting of tablets, capsules, granules and pellets, said composition comprising:
- (I) at least one pharmacologically active compound,
- (II) at least one pharmacologically acceptable auxiliary,
- (III) polyvinylpyrrolidone,
- (IV) a carboxymethyl cellulose polymer having an acidic number between 100 and 1,200 mg of KOH/g of polyrmr solid substance, and
- (V) optionally a gas-forming additive,
- the polymers (III) and (IV) being present in the form of a homogeneous mixture on the molecular level, the mixture being present in 30-90% by weight of the composition, the weight ratio of (III):(IV) ranging from 80:20 to 95:5, and
- the composition in dry compressed state being able to absorb many times its weight of acidic water thereby to form a highly swollen gel of high mechanical and dimensional stability capable of improved prolonged release of the pharmacologically active compound.
4 more elements
Dependencies are inferred from the claim text.