Oral pharmaceutical preparation embedded in an oily matrix and methods of making the same
AssigneeYung Shin Pharmaceutical Industrial Co., Ltd.
InventorsGan-Lin Chen, Wen-Yi Hsu
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Abstract
The present invention relates to an oral pharmaceutical preparation which contains an acid or base labile pharmaceutical ingredient which is embedded in an oily matrix which is controlled at neutral pH. The oily matrix-embedded pharmaceutical ingredient is encapsulated and then being coated by an enteric coating. The enteric coating enables the pharmaceutical ingredient to reach the small intestine for absorption. The oily matrix has the advantages of avoiding acidic or basic conditions. It can also isolate moisture and oxygen so as to allow for greater absorption and bioavailability of the pharmaceutical ingredient in vivo.
Claims18
An oral pharmaceutical preparation comprising:
- an active pharmaceutical ingredient embedded in an oily matrix, wherein said active pharmaceutical ingredient is an acid labile or base labile pharmaceutical ingredient which is one selected from the group consisting of a substituted benzimidazole, an ester, a lactone, an amide, a lactam, an oxime, an imide, a malonic urea, a phenol, a catecholamide, an ether, a thiol, a thioether, a carboxylic acid, a nitrite, or an aldehyde;
- wherein said substituted benzimidazole is a free base omeprazole;
- said oily matrix-embedded active pharmaceutical ingredient being enclosed in a capsule;
- and
- said capsule being coated by an enteric coating.
Dependencies are inferred from the claim text.