Therapeutic inhibitor of vascular smooth muscle cells
AssigneeNeoRx Corporation
InventorsLawrence L. Kunz, John M. Reno
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Abstract
Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.
Claims36
A method for biologically stenting a traumatized mammalian blood vessel, which method comprises administering to the blood vessel an amount of a cytoskeletal inhibitor in a liquid vehicle effective to biologically stent the vessel.
A method for biologically stenting a traumatized mammalian blood vessel, which method comprises administering to the blood vessel a dosage form comprising an amount of a cytochalasin or an anlog thereof in a liquid vehicle effective to biologically stent the vessel, wherein the cytochalasin or analog thereof is at about 0.001 to about 25 μg per ml of liquid vehicle.
A therapeutic method comprising inhibiting diminution of vessel lumen diameter by administering to a traumatized vessel of a mammal an effective amount of a dosage form comprising a cytoskeletal inhibitor, wherein the cytoskeletal inhibitor is administered via an implantable device, and wherein the implantable device is not a catheter having a first and a second expansile member which are disposed on opposite sides of the portion of the traumatized vessel to be treated so as to isolate the portion of the traumatized vessel to be treated prior to cytoskeletal inhibitor administration.
A method for maintaining vessel luminal area following vascular trauma, which method comprises administering to the vessel a dosage form comprising a cytostatic amount of a therapeutic agent which does not exhibit substantial cytotoxicity, wherein the therapeutic agent is a cytoskeletal inhibitor.
A method to inhibit or reduce vascular remodeling of a traumatized mammalian blood vessel, which method comprises administering to the blood vessel a cytostatic amount of a cytoskeletal inhibitor effective to inhibit or reduce vascular remodeling of the traumatized vessel, wherein the vascular remodeling is characterized by constriction of the interior lumen diameter or area of the vessel.
Dependencies are inferred from the claim text.