Compounds and methods for the diagnosis and treatment of EHRLICHIA infection
AssigneeCorixa Corporation
InventorsSteven G. Reed, Michael J. Lodes, Raymond L. Houghton
Life of this patent
Estimating the term…
Abstract
Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
Claims14
A composition comprising a polypeptide and a non-specific immune response enhancer, wherein the polypeptide comprises an immunogenic portion of an amino acid sequence encoded by a DNA sequence selected from the group consisting of:
- SEQ ID NO:
- 2;
- complements of SEQ ID NO:
- 2;
- and DNA sequences that hybridize to SEQ ID NO:
- 2 under moderately stringent conditions.
A fusion protein comprising an immunogenic portion of an amino acid sequence encoded by a DNA sequence selected from the group consisting of:
- SEQ ID NO:
- 2;
- complements of SEQ ID NO:
- 2;
- and DNA sequences that hybridize to SEQ ID NO:
- 2 under moderately stringent conditions.
A diagnostic kit comprising:
- (a) at least one polypeptide comprising an immunogenic portion of an amino acid sequence encoded by a DNA sequence selected from the group consisting of:
- SEQ ID NO:
- 2;
- complements of SEQ ID NO:
- 2;
- and DNA sequences that hybridize to SEQ ID NO:
- 2 under moderately stringent conditions;
- and
- (b) a detection reagent.
Dependencies are inferred from the claim text.