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AssigneeCorixa Corporation
InventorsSteven G. Reed, Michael J. Lodes, Raymond Houghton, Paul R. Sleath
Estimating the term…
Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.
An isolated polypeptide comprising an immunogenic portion of a Babesia microti antigen encoded by SEQ ID NO:
An isolated polypeptide comprising at least two contiguous antigenic epitopes of a Babesia microti antigen, each antigenic epitope comprising the amino acid sequence -X1-X2-X3-X4-X5-Ser (SEQ ID NO:
An antigenic epitope of a Babesia microti antigen comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
A fusion protein comprising at least one polypeptide selected from the group consisting of:
A vaccine comprising a non-specific immune response enhancer and at least one polypeptide selected from the group consisting of:
A vaccine comprising a non-specific immune response enhancer and at least one antigenic epitope of a Babesia microti antigen, the antigenic epitope comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
Dependencies are inferred from the claim text.