Catalyzed water-soluble/dispersible reactive derivatives of polyimido compounds for modifying proteinaceous substrates

A method for treating a proteinaceous substrate which comprises the steps of:

• (a) contacting a polyimido compound with an aqueous of solution an nucleophilic catalytic agent to form a mixture, wherein the pH value of the aqueous solution of nucleophilic catalytic agent is such that when the aqueous nucleophilic catalytic agent is mixed with the polyimido compound, the resulting mixture will have a pH in a range sufficient to enable the nucleophilic catalytic agent to react with the polyimido compound;
• and
• (b) contacting the mixture from step (a) with a proteinaceous substrate for a time sufficient to allow the mixture to react with the proteinaceous substrate;
• wherein the polyimido compound is selected from the group consisting of polysuccinimide compounds represented by Formula (1):
• polyglutimide compounds represented by Formula (2);
• polysuccinimide compounds represented by Formula (3):
• polyglutimide compounds represented by Formula (4);
• copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2);
• and copolymers of the polysuccinimide compounds represented by Formula (3) with the polyglutimide compounds represented by Formula (4);
• wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound;
• F is a functionalizing moiety that provides functionality to the polyimido compound;
• the ratio of n1 to n2 is from about 1:99 to about 99:1;
• the ratio of n3:n4:n5 is from about 1:1:98 to about 45:45:10;
• and the molecular weight of the polyimido compound is from about 300 to about 1,000,000.

A composition useful for treating a proteinaceous substrate which comprises an aqueous mixture of a polyimido compound and a nucleophilic catalytic agent having a pH value in a range sufficient to enable the nucleophilic catalytic agent to covalently bond with the polyimido compound;

• wherein the polyimido compound is selected from the group consisting of polysuccinimide compounds represented by Formula (1):
• polyglutimide compounds represented by Formula (2);
• polysuccinimide compounds represented by Formula (3):
• polyglutimide compounds represented by Formula (4);
• copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2);
• and copolymers of the polysuccinimide compounds represented by Formula (3) with the polyglutimide compounds represented by Formula (4);
• wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound;
• F is a functionalizing moiety that provides functionality to the polyimido compound;
• the ratio of n1 to n2 is from about 1:99 to about 99:1;
• the ratio of n3:n4:n5 is from about 1:1:98 to about 45:45:10;
• and the molecular weight of the polyimido compound is from about 300 to about 1,000,000.

A method for treating a proteinaceous substrate which comprises the steps of:

• (a) contacting an imido or polyimido compound with an aqueous solution of an nucleophilic catalytic agent to form a mixture, wherein the pH value of the aqueous solution of nucleophilic catalytic agent is such that when the aqueous nucleophilic catalytic agent is mixed with the imido or polyimido compound, the resulting mixture will have a pH in a range sufficient to enable the nucleophilic catalytic agent to covalently bond with the imido or polyimido compound;
• wherein the imido or polyimido compound has attached thereto a functionalizing moiety F that provides functionality to the imido or polyimido compound;
• and
• (b) contacting the mixture from step (a) with a proteinaceous substrate for a time sufficient to allow the mixture to react with the proteinaceous substrate.