Microparticles that contain gas, galactose and a saturated fatty acid
AssigneeSchering Corporation
InventorsDieter Heldmann, Werner Weitschies, Thomas Fritzsch, Ulrich Speck
Life of this patent
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Abstract
Compositions containing microparticles having at least one surface-active substance and at least one non-surface-active solid with a gaseous component containing a halogenated hydrocarbon that is gaseous at body temperature, wherein the gaseous component is more poorly water-soluble than air. Also, ultrasonic contrast media containing such composition, processes for their production, kits for their production and methods of use.
Claims15
A composition for the preparation of an ultrasonic contrast medium which comprises microparticles that comprise a mixture of galactose and at least one saturated C12-C26 fatty acid and at least one of perfluoropropane, perfluorobutane or hexafluoroethane which is gaseous at body temperature and more poorly water-soluble than air.
A composition for the preparation of an ultrasonic contrast medium that is blood-isotonic or substantially blood-isotonic which comprises microparticles that comprise a mixture of galactose and at least one saturated C12-C26 fatty acid and at least one of perfluoropropane, perfluorobutane or hexafluoroethane which is gaseous at body temperature and more poorly water-soluble than air.
A composition for the preparation of an ultrasonic contrast medium which comprises microparticles in a liquid suspension medium at a concentration of 3-50 mg of microparticles per ml of liquid suspension medium, wherein said microparticles comprise a mixture of galactose, at least one saturated C12-C26 fatty acid and at least one of perfluoropropane, perfluorobutane or hexafluoroethane which is gaseous at body temperature and more poorly water-soluble than air.
Dependencies are inferred from the claim text.