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US 6,306,365 B1Granted
Method of identifying molecules that home to a selected organ in vivo
AssigneeThe Burnham Institute
InventorsErkki Ruoslahti, Renata Pasqualini
Life of this patent
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Abstract
The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
Claims19
A method of recovering a plurality of molecules that home to a selected organ or tissue, comprising the steps of:
- a. administering to a subject a library of diverse molecules, wherein each of said diverse molecules is linked to a tag that facilitates recovery of said molecules, providing said library of molecules is not a nucleic acid library;
- b. collecting a sample of the selected organ or tissue;
- and
- c. recovering from said sample a plurality of molecules that home to said selected organ or tissue by isolating molecules comprising said tag from said sample.
1 more element
A method of identifying a molecule that homes to a selected organ or tissue, comprising the steps of:
- a. administering to a subject a library of diverse molecules, wherein each of said diverse molecules is linked to a tag that facilitates recovery of said molecules and provided said library of molecules is not a nucleic acid library;
- b. collecting a sample of the selected organ or tissue;
- c. recovering from said sample a plurality of molecules that home to said selected organ or tissue by isolating molecules comprising said tag from said sample;
- and
- d. identifying a molecule that homes to said selected organ or tissue.
2 more elements
A method of identifying a molecule that homes to a selected organ or tissue, comprising the steps of:
- a. administering to a subject a library of diverse molecules, wherein each of said diverse molecules is linked to a unique oligonucleotide tag and provided said library of molecules is not a nucleic acid library;
- b. collecting a sample of the selected organ or tissue;
- and
- c. identifying a unique oligonucleotide tag present in said sample, thereby identifying a molecule that homes to said selected organ or tissue.
1 more element
Dependencies are inferred from the claim text.