ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin
AssigneeMeadox Medicals, Inc.
InventorsBirendra K. Patnaik, Horng-Ban Lin, David J. Lentz, Richard J. Zdrahala
Life of this patent
Estimating the term…
Abstract
Disclosed are implantable medical devices with enhanced patency. Expanded polytetrafluoroethylene small caliber vascular grafts coated with polymer bound bio-active agents that exhibit enhanced patency are disclosed. The polymer bound bio-active agents can include anti-thrombogenic agents, antibiotics, antibacterial agents and antiviral agents. Methods of preparing same are also provided.
Claims4
An implantable medical device having at least one hydrophobic surface, said surface having a bio-active coating bound thereto, said bioactive coating containing a polymer backbone bound via an amide or an amine linkage to a first end of a hydrophilic, amine-terminated spacer, said spacer having at least one amine group at each of its first and second ends, said hydrophilic spacer being covalently bound to a bio-active molecule via its second end, said hydrophilic spacer further being repelled by said hydrophobic surface such that the bio-active molecule is extended away from said hydrophobic surface, wherein said bio-active coating further comprises a polymer structure defined by a bio-compatible polymeric backbone and at least one pendant moiety selected from the group consisting of:
- wherein R1 is
- R2 is a spacer group selected from the group consisting of oxygenated polyolefins, aliphatic polyesters, polyamino acids, polyamines, hydrophilic polysiloxanes, hydrophilic polysilazanes, hydrophilic acrylates, hydrophilic methacrylates, linear polysaccharides and lightly branched polysaccharides;
- and R3 is a bio-active agent selected from the group consisting of antithrombogenic agents, antibiotics, antibacterial agents, antiviral agents, pharmaceutical salts thereof and mixtures thereof.
A medical device having a bio-active coating over a body fluid contacting surface of said medical device for contacting body fluids, wherein said body fluid contacting surface is covalently bonded to said bio-active coating, said coating comprising a polymeric structure, said polymeric structure defined by a bio-compatible polymeric backbone and at least one pendant moiety selected from the group consisting of:
- wherein R1 is
- R2 is a spacer group selected from the group consisting of oxygenated polyolefins, aliphatic polyesters, polyamino acids, polyamines, hydrophilic polysiloxanes, hydrophilic polysilazanes, hydrophilic acrylates, hydrophilic methacrylates, linear polysaccharides, and lightly branched polysaccharides;
- and R3 is a bio-active agent selected from the group consisting of antithrombogenic agents, antibiotics, antibacterial agents, antiviral agents, thereof pharmaceutical salts, and mixtures thereof.
A surface-modified implantable sheet material whose treated surface when exposed to a body fluid is bioactive over extended periods of time comprising:
- a hydrophobic substrate material having a plasma induced hydrophilic functionality and a bio-active coating covalently bonded to said substrate material wherein the bio-active coating has a polymeric structure defined by a bio-compatible polymeric backbone and at least one pendant moiety selected from the group consisting of:
- wherein R1 is
- R2 is a spacer group selected from the group consisting of oxygenated polyolefins, aliphatic polyesters, polyamino acids, polyamines, hydrophilic polysiloxanes, hydrophilic polysilazanes, hydrophilic acrylates, hydrophilic methacrylates, linear polysaccharides, and lightly branched polysaccharides;
- and R3 is a bio-active agent selected from the group consisting of antithrombogenic agents, antibiotics, antibacterial agents, antiviral agents, pharmaceutical salts thereof and mixtures thereof.
Dependencies are inferred from the claim text.