Compounds

A method of treating rheumatoid arthritis which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I)

• wherein x represents 1 or 2;
• A represents a group CH2;
• B represents a hydrogen or halogen atom;
• R represents a phenyl, pyridyl, indolyl, indazolyl, pyrimidinyl or thienyl group, each of which may be optionally substituted by one or more substituents independently selected from
• (i) halogen, amino, cyano, hydroxyl, nitro, C1-C6-alkyl, halo-C1-C6-alkyl, —N(R1)—C(═O)—R2, —NR5R6, C3-C8-cycloalkyl, 3- to 8-membered heterocyclyl, C3-C8-cycloalkyloxy, C1-C6-alkylcarbonyl, C1-C6-alkylsulphinyl, C1-C6-alkylsulphonyl, and
• (ii) C1-C6-alkoxy, C1-C6-alkylamino, phenoxy, benzyl, C1-C6-alkylthio and phenylthio each of which may be optionally substituted by one or more substituents independently selected from halogen, amino, cyano, carboxyl, hydroxyl, nitro, 1-pyrrolidinyl, 1-piperidinyl, C1-C6-alkyl, C1-C6-alkoxy, (di)C1-C6-alkylamino, halo-C1-C6-alkyl, C1-C6-alkoxycarbonyl,
• R1 represents a hydrogen atom or a C1-C6-alkyl or C3-C8-cycloalkyl group;
• R2 represents a C1-C6-alkyl or C3-C8-cycloalkyl group;
• R5 represents a hydrogen atom or a C1-C6-alkyl or C3-C8-cycloalkyl group;
• R6 represents a C3-C8-cycloalkyl group and, additionally, a C1-C6-alkyl group when R5 is not a hydrogen atom;
• R7 represents a hydrogen atom or a C1-C6-alkyl or C3-C8-cycloalkyl group;
• R8 represents a C1-C6-alkyl or C3-C8-cycloalkyl group;
• R9 represents a hydrogen atom or a hydroxyl group;
• and
• R10 represents a hydrogen atom or a phenyl or imidazolyl group;
• with the proviso that when B represents a hydrogen atom and R is a phenyl- or pyridyl-containing group, the phenyl or pyridyl moiety is substituted as defined above;
• or a pharmaceutically acceptable salt or solvate thereof.