Devices for sealing punctures in body vessels

A closure device for sealing a puncture in a body vessel comprising:

• a sealer/dilator for dilating tissue adjacent a vessel puncture, the sealer/dilator including a proximal end and a distal end sized to not enter the vessel,
• at least two closure composition precursor lumens within the sealer/dilator having entrance ports adjacent the proximal end of the sealer/dilator through which one or more fluent closure composition precursors can be delivered into the closure composition precursor lumen, and exit ports adjacent the distal end of the sealer/dilator through which the one or more fluent closure compositions can be delivered outside the vessel adjacent the vessel puncture, the at least two closure composition precursor lumens being connected at a junction within the sealer/dilator,
• a static mixer connected at the junction to cause mixing of closure composition precursor carried within each lumen, and
• a plugging catheter for positioning within the vessel puncture, the plugging catheter extending distally from the sealer/dilator and including at least one positioning sensing mechanism such that the exit port of the closure composition precursor lumen is outside the vessel when the at least one position sensing mechanism is detected to be outside the vessel.

A closure device for sealing a puncture in a body vessel comprising:

• a catheter having a proximal end and a distal end;
• and
• at least two closure composition precursor lumens within the catheter having entrance ports adjacent the proximal end of the catheter through which one or more fluent closure composition precursors can be delivered into the closure composition precursor lumen, and exit ports adjacent the distal end of the catheter through which the one or more fluent closure composition precursors can be delivered outside the vessel adjacent the vessel puncture, the at least two closure composition precursor lumens being connected at a junction within the catheter, and
• a static mixer connected at the junction to cause mixing of closure composition precursor carried within each lumen.

An assembly for introducing a closure material to seal a vessel puncture site, the closure material comprising a mixture of a first and a second fluid composition which, upon mixing, react to form a nonfluent closure composition, the assembly comprising:

• a catheter for passage through a tissue puncture and having a distal end, at least one fluid delivery port adjacent the catheter distal end to occupy a position adjacent the vessel puncture site, and a lumen in the catheter in fluid communication with the fluid delivery port;
• one or more dispensers in fluid communication with the catheter lumen for dispensing the first and second fluid compositions into the catheter lumen;
• and
• an actuator for causing the first and second fluid compositions to be dispensed from the one or more dispensers into the catheter lumen, mixed by flowing the first and second fluid compositions through the catheter lumen, and dispensed from the fluid delivery port as a fluid mixture that reacts in situ to form the nonfluent closure composition adjacent the vessel puncture site;
• wherein the catheter is sized to block flow of the fluid mixture from the fluid delivery port into a substantial part of the tissue puncture, whereby a localized in situ closure forms adjacent the vessel puncture site to seal the vessel puncture site.

A method for sealing a vascular puncture site comprising the steps of introducing a catheter through a tissue puncture, the catheter including a distal end and at least one fluid delivery port adjacent the distal end to be positioned adjacent the vessel puncture site, the catheter being sized to occupy substantially all of the tissue puncture;

• providing first and second fluid compositions which, upon mixing, react to form a nonfluent closure composition;
• mixing the first and second fluid compositions by flowing the components through a lumen in the catheter that communicates with the fluid delivery port;
• and
• dispensing the first and second fluid compositions from the fluid delivery port as a fluid mixture that reacts in situ to form the nonfluent closure composition adjacent the vessel puncture site, the size of the catheter blocking flow of the fluid, mixture from the fluid delivery port into a substantial part of the tissue puncture, whereby a localized in situ closure forms adjacent the vessel puncture site to seal the vessel puncture site.