# US 6,297,379 B1 · Thienopyrimidine compounds, their production and use

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- Number: US 6,297,379 B1
- Document ID: US6297379B1
- Status: Granted
- Kind: B1
- Application number: 09/530,495
- Filed: 2000-04-26
- Granted: 2001-10-02
- Earliest claimed: 1999-03-24
- Assignees: Takeda Chemical Industries, Ltd.
- Inventors: Shuichi Furuya; Nobuhiro Suzuki; Nobuo Choh; Yoshi Nara
- Web page: https://patentgrep.com/patent/US6297379B1

## CPC

- C07D 495/04: Ortho-condensed systems
- A61P 5/02: of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound of formula (I) wherein R1 and R2 each is hydrogen, hydroxy, C1-4 alkoxy, C1-4 alkoxy-carbonyl or C1-4 alkyl which may be substituted; R3 is hydrogen, halogen, hydroxy or C1-4 alkoxy which may be substituted; or adjacent two R3 may form C1-4 alkylenedioxy; R4 is hydrogen or C1-4 alkyl; R6 is C1-4 alkyl which may be substituted or a group of the formula (A) wherein R5 is hydrogen of R4 and R5 may form heterocycle; and n is 0-5, or a salt thereof, has an excellent GnRH-antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases.

## Claims

### Claim 1

5-(N-Benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-(3-methoxyureido)phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or a salt thereof.