Bioadhesive polymer compositions
AssigneePMD Holdings Corp.
InventorsNancy S. Marchant, Simon Hsaio-Pao Yu, Zahid Amjad
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Abstract
Improved crosslinked ionic polymers or salts thereof having a soluble polymer fraction of less than about 15 wt %, and methods for making the same. The polymers are useful as bioadhesives, thickeners, emulsifiers, suspending aids, and pharmaceutical controlled release excipients.
Claims43
A crosslinked ionic polymer or salt thereof substantially free of soluble polymer and having at least one of the following features when in deionized water at a concentration of 0.5 wt %:
- (i) a yield stress of between about 10 and about 200 Pa, (ii) a Brookfield viscosity of between about 2,000 and about 150,000 mPa S, and (iii) a microviscosity value of between about 0.01 and about 25.0 Pa S.
A crosslinked ionic polymer or salt thereof having a reduced concentration of soluble polymer and further having at least one of the following features when in deionized water at a concentration of 0.5 wt %:
- (i) a yield stress of between about 10 and about 200 Pa, (ii) a Brookfield viscosity of between about 2,000 and about 150,000 mPa S, and (iii) a microviscosity value of between about 0.01 and about 25.0 Pa S,
- the polymer being produced by extracting soluble polymer from a polymer reaction product composed of a mixture of a soluble polymer fraction and a crosslinked polymer fraction to thereby produce a crosslinked polymer product with a reduced concentration of soluble polymer.
Dependencies are inferred from the claim text.