# US 6,297,030 B1 · Human Wnt-7a polynucleotides

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- Number: US 6,297,030 B1
- Document ID: US6297030B1
- Status: Granted
- Kind: B1
- Application number: 09/459,774
- Filed: 1999-12-13
- Granted: 2001-10-02
- Earliest claimed: 1998-12-23
- Assignees: SmithKline Beecham Corporation
- Inventors: Michael Robert Barnes; Tania Tamson Testa
- Web page: https://patentgrep.com/patent/US6297030B1

## CPC

- C07K 14/475: Growth factors; Growth regulators
- G01N 33/50: Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing (measuring or testing processes involving enzymes or microorganisms, compositions or test papers therefor; processes for forming such compositions, condition responsive control in microbiological or enzymological processes C12Q)
- G01N 33/53: Immunoassay; Biospecific binding assay; Materials therefor
- C07K 2319/30: Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Wnt-7a polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-7a polypeptides and polynucleotides in therapy, and diagnostic assays for such.

## Claims

### Claim 1

An isolated polynucleotide comprising the polynucleotide of SEQ ID NO:1.

### Claim 2 (depends on 1)

An expression vector comprising the polynucleotide sequence of claim 1, encoding a polypeptide sequence of SEQ ID NO:2 when said expression vector is present in a compatible host cell.

### Claim 3 (depends on 2)

A process for producing a recombinant host cell which comprises the step of introducing the expression vector of claim 2 into a cell such that the host cell, under appropriate culture conditions, produces said polypeptide.

### Claim 4 (depends on 3)

A recombinant host cell produced by the process of claim 3.

### Claim 5 (depends on 4)

A membrane of a recombinant host cell of claim 4 expressing said polypeptide.

### Claim 6 (depends on 4)

A process for producing a polypeptide which comprises culturing a host cell of claim 4 under conditions sufficient for the production of said polypeptide and recovering said polypeptide from the culture.

### Claim 7 (depends on 1)

The isolated polynucleotide of claim 1 consisting of the polynucleotide sequence set forth in SEQ ID NO:1.

### Claim 8 (depends on 1)

The isolated polynucleotide of claim 1, comprising a polynucleotide sequence encoding the polypeptide of SEQ ID NO:2.

### Claim 9 (depends on 1)

The isolated polynucleotide of claim 1, encoding the polypeptide consisting of the polypeptide set forth in SEQ ID NO:2.