# US 6,296,832 B1 · Molecules that home to a selected organ in vivo

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- Number: US 6,296,832 B1
- Document ID: US6296832B1
- Status: Granted
- Kind: B1
- Application number: 09/226,985
- Filed: 1999-01-08
- Granted: 2001-10-02
- Earliest claimed: 1995-09-11
- Assignees: The Burnham Institute
- Inventors: Erkki Ruoslahti; Renata Pasqualini
- Web page: https://patentgrep.com/patent/US6296832B1

## CPC

- A61K 49/0008: {Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure}
- C12Q 1/6883: for diseases caused by alterations of genetic material
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

The present invention provides enriched library fractions containing a plurality of molecules that home to a selected organ in vivo.

## Claims

### Claim 1

An enriched library fraction containing a plurality of molecules that selectively home to a selected organ or tissue, said enriched library fraction recovered by in vivo panning, comprising the steps of:
a) administering to a subject a library of diverse molecules, wherein each of said molecules is attached to a tag that facilitates recovery of said molecules;
b) collecting a sample of the selected organ or tissue; and
c) recovering from said sample said enriched library fraction containing a plurality of molecules that selectively home to said selected organ or tissue,
wherein said library of diverse molecules is not a nucleic acid library.

### Claim 2 (depends on 1)

The enriched library fraction of claim 1, wherein said selected organ or tissue is brain.

### Claim 3 (depends on 1)

The enriched library fraction of claim 1, wherein said selected organ or tissue is kidney.

### Claim 4 (depends on 1)

The enriched library fraction of claim 1, wherein said organ or tissue is a tumor.

### Claim 5 (depends on 1)

The enriched library fraction of claim 1, wherein said molecules are s elected from the group consisting of peptides, peptidomimetics, proteins and fragments of proteins.

### Claim 6

An enriched library fraction containing a plurality of molecules that target the vasculature of a selected organ or tissue, said enriched library fraction recovered by in vivo panning, comprising the steps of:
a) administering to a subject a library of diverse molecules, wherein each of said molecules is attached to a tag that facilitates recovery of said molecules;
b) collecting a sample of the selected organ or tissue; and
c) recovering from said sample said enriched library fraction containing a plurality of molecules that target the vasculature of said selected organ or tissue,
wherein said library of diverse molecules is not a nucleic acid library.

### Claim 7 (depends on 6)

The enriched library fraction of claim 6, wherein said selected organ or tissue is brain.

### Claim 8 (depends on 6)

The enriched library fraction of claim 6, wherein said selected organ or tissue is kidney.

### Claim 9 (depends on 6)

The enriched library fraction of claim 6, wherein said organ or tissue is a tumor.

### Claim 10 (depends on 6)

The enriched library fraction of claim 6, wherein said molecules are selected from the group consisting of peptides, peptidomimetics, proteins and fragments of proteins.