# US 6,296,126 B1 · Device for removing a liquid from capillaries > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 6,296,126 B1 - Document ID: US6296126B1 - Status: Granted - Kind: B1 - Application number: 09/469,243 - Filed: 1999-12-22 - Granted: 2001-10-02 - Earliest claimed: 1998-12-23 - Assignees: Microparts Gesellschaft - Inventors: Ralph-Peter Peters - Web page: https://patentgrep.com/patent/US6296126B1 ## CPC - B01J 19/0093: {Microreactors, e.g. miniaturised or microfabricated reactors (laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027)} - B01L 3/502746: {characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves} - B01J 2219/00891: Feeding or evacuation - B01L 3/50273: {characterised by the means or forces applied to move the fluids} - B01L 2300/0681: Filter - B01L 2300/0816: Cards, e.g. flat sample carriers usually with flow in two horizontal directions - B01L 2300/0825: Test strips - B01L 2400/0406: capillary forces - B01L 2400/0457: passive flow or gravitation - B01L 2400/084: Passive control of flow resistance - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS - B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE ## Abstract Liquid components are separated from a liquid using separation devices, such as filters and membranes, in which capillary forces, which retain the liquid component to be separated in the separation device, are effective. If the amount of liquid is very small, it can be very difficult to remove the liquid component to be separated in the separation device in a free and unchanged form. This process step is simplified or facilitated by a wedge-shaped cut-out at an exit end of the capillary or in a columnar body which is in contact with an exit end of the capillary. A radius of curvature of a wedge edge is smaller than a radius of the capillary. A base side of the wedge-shaped cut-out is adjacent to a collecting chamber in which the separated-off liquid component is collected, and in which the capillary forces are smaller than interfering forces in the capillary itself. If interfering capillary forces are still effective in the collecting chamber, then a further wedge-shaped cut-out can be provided at the exit end of the collecting chamber. Thus, the device makes it possible to separate off liquid components in the microliter range. ## Claims ### Claim 1 A device for removing a liquid from at least one capillary into a collecting chamber, wherein: in each case, there is a wedge-shaped cut-out in a body at an exit end into which the at least one capillary runs; a radius of curvature of a wedge edge of the cut-out is smaller than half the smallest dimension of the largest capillary which runs into the wedge-shaped cut-out; a wedge angle between wedge surfaces of the cut-out in a vicinity of the wedge edge is less than 150 degrees; and said collecting chamber is adjacent to a base side of the wedge-shaped cut-out. ### Claim 2 (depends on 1) A device according to claim 1, wherein: said wedge angle between the wedge surfaces of the cut-out in the vicinity of the wedge edge is less than ninety degrees. ### Claim 3 (depends on 1) A device according to claim 1 in a two-piece shape configured to remove a liquid from at least one capillary which passes through a first body into a second collecting chamber which is provided in a second body, wherein: said at least one wedge-shaped cut-out into which the at least one capillary runs at its exit end is provided in at least one projection which is located on a base plate as the second body; a free end of the at least one projection is in contact with a surface of the first body in which the exit end of the at least one capillary is located; and a beginning of the wedge edge of the wedge-shaped cut-out is within an exit area of the at least one capillary. ### Claim 4 (depends on 3) A device according to claim 3, wherein the at least one capillary is: a single capillary in the first body. ### Claim 5 (depends on 3) A device according to claim 3, wherein: said wedge edge of the wedge-shaped cut-out is perpendicular or inclined by an angle of at least twenty degrees to the surface of the first body in which the exit end of the at least one capillary is located. ### Claim 6 (depends on 3) A device according to claim 3, wherein: said at least one wedge-shaped cut-out is provided in at least one projection which has the shape of a column. ### Claim 7 (depends on 1) A device according to claim 1 in a one-piece shape, wherein: in each case, the wedge-shaped cut-out runs seamlessly into the at least one capillary at the exit end thereof. ### Claim 8 (depends on 7) A device according to claim 7, wherein: said wedge-shaped cut-out is provided in a wall of the collecting chamber into which the at least one capillary runs; and a beginning of the wedge edge of the wedge-shaped cut-out is located in a wall of the capillary in a vicinity of the exit end thereof. ### Claim 9 (depends on 8) A device according to claim 8, wherein: said wedge edge of the wedge-shaped cut-out is perpendicular or inclined to an angle of at least twenty degrees to the wall of the capillary. ### Claim 10 (depends on 1) A device according to claim 1, wherein: a plurality of groups, which each comprise at least one wedge-shaped cut-out and a collecting chamber, is arranged one after the other; and a dimension determining a capillarity of the collecting chamber is greater than a capillarity-determining dimension of a respective collecting chamber arranged therebefore. ### Claim 11 (depends on 1) A device according to claim 1, wherein said device is configured to separate a liquid from a liquid medium. ### Claim 12 (depends on 11) A device according to claim 11, wherein said device is configured for one of: separating the liquid from a solid-containing medium by a filter membrane; separating blood plasma from whole blood by a separator membrane; and filling a well of a microtiter plate from a feed capillary. ### Claim 13 (depends on 3) A device according to claim 3, wherein at least one capillary is: a plurality of discrete capillaries or gaps passing through the first body. ### Claim 14 (depends on 3) A device according to claim 3, wherein at least one capillary is: a plurality of pores or gaps in the first body which is an open-pore membrane. ### Claim 15 (depends on 3) A device according to claim 3, wherein the at least one capillary is: an open-pore sintered body. ### Claim 16 (depends on 3) A device according to claim 3, wherein the at least one capillary is one of: a nonwoven, a felt or a paper. ### Claim 17 (depends on 3) A device according to claim 3, wherein: said at least one wedge-shaped cut-out is provided in at least one projection which has the shape of a cone. ### Claim 18 (depends on 3) A device according to claim 3, wherein: said at least one wedge-shaped cut-out is provided in at least one projection which has the shape of a pyramid. ### Claim 19 (depends on 3) A device according to claim 3, wherein: said at least one wedge-shaped cut-out is provided in at least one projection which has the shape of a cross piece.