# US 6,294,675 B1 · Process for preparing eprosartan using regioselective protection of 2,4-disubstituted-imidazole intermediates

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- Number: US 6,294,675 B1
- Document ID: US6294675B1
- Status: Granted
- Kind: B1
- Application number: 09/355,186
- Filed: 1999-07-27
- Granted: 2001-09-25
- Earliest claimed: 1997-02-14
- Assignees: SmithKline Beecham Corporation
- Inventors: Richard T. Matsuoka; Peng Liu
- Web page: https://patentgrep.com/patent/US6294675B1

## CPC

- C07D 233/64: with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/04: Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 9/12: Antihypertensives
- A61P 13/12: of the kidneys
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 409/06: linked by a carbon chain containing only aliphatic carbon atoms
- Y02P 20/55: Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02P: CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

## Abstract

This invention relates to a process for preparing eprosartan.

## Claims

### Claim 1

A compound which is
wherein R″ is C1-4 alkyl.

### Claim 2 (depends on 1)

The compound according to claim 1 which is

### Claim 3

A compound which is
wherein R′ and R″ independently are C1-4 alkyl.

### Claim 4 (depends on 3)

The compound according to claim 3 which is

### Claim 5

A compound which is
wherein:
R′ is C1-4 alkyl;
R″ is C1-4 alkyl; and R′″ is C1-4 alkyl.

### Claim 6 (depends on 5)

The compound according to claims 5 which is