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AssigneeNitroMed, Inc.
InventorsDavid S. Garvey, Joseph D. Schroeder, Inigo Saenz de Tejada
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The present invention describes novel compositions and kits comprising alpha-adrenergic receptor antagonists and compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, or stimulate nitric oxide synthesis. In preferred embodiments, the alpha-adrenergic receptor antagonist is an alkaloid selected from the group consisting of rauwolscine, corynanthine, yohimbine, apoyohimbine, beta-yohimbine, yohimbol, pseudoyohimbine and epi-3α-yohimbine, and the compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, or stimulates nitric oxide synthesis is selected from the group consisting of L-arginine, S-nitroso-N-acetylcysteine, S-nitroso-captopril, S-nitroso-homocysteine, S-nitroso-cysteine and S-nitroso-glutathione. In other embodiments, the present invention describes novel compositions comprising yohimbine and L-arginine. In still other embodiments, the invention describes novel compositions comprising yohimbine and L-arginine where the yohimbine is derived from yohimbe bark or Rauwolfia root. The novel compositions of the invention are useful for treating impotence in males and females.
A composition comprising an alkaloid selected from the group consisting of rauwolscine, corynanthine, yohimbine, apoyohimbine, α-yohimbine, yohimbol, pseudoyohimbine, and epi-3α-yohimbine, and a compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, or stimulates nitric oxide synthesis selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-captopril, S-nitroso-homocysteine, S-nitroso-cysteine, S-nitroso-glutathione, and L-arginine, in an amount effective to treat human impotence.
A composition comprising yohimbine and L-arginine in an amount effective to treat human impotence.
A composition comprising yohimbine and L-arginine, wherein the yohimbine is obtained from yohimbe bark or Rauwolfia root, in an amount effective to treat human impotence.
An orally administrable composition comprising yohimbine and L-arginine in an amount effective to treat human impotence.
An orally administrable composition comprising yohimbine and L-arginine, wherein the yohimbine is obtained from yohimbe bark or Rauwolfia root, in an amount effective to treat human impotence.
A kit comprising an alkaloid selected from the group consisting of rauwolscine, corynanthine, yohimbine, apoyohimbine, β-yohimbine, yohimbol, pseudoyohimbine, and epi-3α-yohimbine and a compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, or stimulates nitric oxide synthesis selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-captopril, S-nitroso-homocysteine, S-nitroso-cysteine, S-nitroso-glutathione, and L-arginine, in an amount effective to treat human impotence.
A kit comprising yohimbine and L-arginine, in an amount effective to treat human impotence.
A kit comprising yohimbine and L-arginine, wherein the yohimbine is obtained from yohimbe bark or Rauwolfia root, in an amount effective to treat human impotence.
A method of treating human impotence in an individual in need thereof comprising administering to the individual an effective amount of an alkaloid selected from the group consisting of rauwolscine, corynanthine, yohimbine, apoyohimbine, β-yohimbine, yohimbol, pseudoyohimbine, and epi-3α-yohimbine and a compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, or stimulates nitric oxide synthesis selected from the group consisting of S-nitroso-N-acetylcysteine, S-nitroso-captopril, S-nitroso-homocysteine, S-nitroso-cysteine, S-nitroso-glutathione, and L-arginine.
A method of treating human impotence in an individual in need thereof comprising administering to the individual an effective amount of a composition comprising yohimbine and L-arginine in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.