# US 6,294,376 B1 · Cholesterol 7-alpha hydroxylase expression regulation

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 6,294,376 B1
- Document ID: US6294376B1
- Status: Granted
- Kind: B1
- Application number: 08/192,271
- Filed: 1994-02-04
- Granted: 2001-09-25
- Earliest claimed: 1993-02-05
- Inventors: Merrill Overturf; David Loose-Mitchell
- Web page: https://patentgrep.com/patent/US6294376B1

## CPC

- C07K 14/4702: {Regulators; Modulating activity}
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

A method for controlling cholesterol is provided. A cholesterol 7-alpha-hydroxylase (C7αH) regulatory factor is administered to control cholesterol catabolism. Also provided is a method for producing the cholesterol control agent and a nucleotide sequence involved in regulatory control.

## Claims

### Claim 1

A DNA fragment comprising the sequence of the rabbit C7αH core promoter.

### Claim 2 (depends on 1)

A DNA fragment according to claim 1 wherein the rabbit C7αH core promoter has the sequence of SEQ ID NO: 8.

### Claim 3

A transformed cell comprising the DNA sequence of the rabbit C7αH core promoter.

### Claim 4 (depends on 3)

A transformed cell according to claim 3 wherein the rabbit C7αH core promoter has the sequence of SEQ ID NO: 8.

### Claim 5

A vector comprising the DNA sequence of the rabbit C7αH core promoters.

### Claim 6 (depends on 5)

A vector according to claim 5 wherein the rabbit C7αH core promoter has the sequence of SEQ ID NO: 8.