# US 6,294,174 B1 · Peptides immunologically related to known viral protein

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- Number: US 6,294,174 B1
- Document ID: US6294174B1
- Status: Granted
- Kind: B1
- Application number: 08/290,736
- Filed: 1994-11-16
- Granted: 2001-09-25
- Earliest claimed: 1992-02-19
- Assignees: Monash University; Centre National De La Recherche Scientifique
- Inventors: Velibor Krsmanovic; Irena Cosic; Jean-Michel Biquard; Milton T. W. Hearn
- Web page: https://patentgrep.com/patent/US6294174B1

## CPC

- C07K 14/005: from viruses
- A61P 31/12: Antivirals
- A61P 31/18: for HIV
- C07K 1/00: General methods for the preparation of peptides {, i.e. processes for the organic chemical preparation of peptides or proteins of any length}
- C07K 14/001: {by chemical synthesis}
- C07K 14/70514: {CD4}
- C07K 16/00: Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- C12N 2740/16122: New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C12N 2740/16222: New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

Peptides immunologically related to proteins expressed by a viral agent, having a sequence of amino acids ordered by means of the protein informational analysis techniques using the Fourier transform method with reference to the amino acid sequence of a target antigen against which antibodies are desired to be formed, or lymphocytes desired to be directed. The sequence has in the Fourier spectrum, one or more frequencies of practically the same value as the frequency of frequencies characteristic of the target antigen.

## Claims

### Claim 1

A peptide consisting of SEQ ID NO: 1.

### Claim 2

A peptide consisting of SEQ ID NO: 2.

### Claim 3

A peptide consisting of SEQ ID NO: 3.

### Claim 4

A peptide consisting of SEQ ID NO: 4.

### Claim 5

A peptide consisting of SEQ ID NO: 5.

### Claim 6

A peptide consisting of SEQ ID NO: 27.