Polymers containing guanidinium groups as bile acid sequestrants
AssigneeGelTex Pharmaceuticals, Inc.
InventorsPradeep K. Dhal, Stephen R. Holmes-Farley, John S. Petersen
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Abstract
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a guanidinium moiety-containing polymer composition to a mammal, such as a human, whereby bile acids are sequestered. The polymers of the invention comprise guanidinium moieties and optionally, additional substituents such as a hydrophobic group, a quaternary ammonium-containing group or a combination thereof.
Claims32
A method for removing bile acids from a patient comprising administering to said patient a therapeutically effective amount of a guanidinium moiety-containing polymer composition, wherein said polymer comprises a repeat unit having an aliphatic backbone characterized in that at least 10 molar percent of the repeat units bear pendant guanidinium substituents.
A method for removing bile acids from a patient comprising administering to said patient a therapeutically effective amount of a guanidinium moiety-containing polymer composition, wherein said polymer comprises at least 10 molar percent of a repeat unit having the following structural formula:
- wherein each R is independently hydrogen, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, a hydrophobic group or a quaternary ammonium-containing group.
A method for removing bile acids from a patient comprising administering to said patient a therapeutically effective amount of a guanidinium moiety-containing polymer composition, wherein said polymer comprises at least 10 molar percent of one or more repeat units selected from:
- wherein n is an integer from two to about twenty;
- and
- R1 and R2 arc each independently hydrogen, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, a hydrophobic group or a quaternary ammonium-containing group.
Dependencies are inferred from the claim text.