Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof
AssigneePLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo
InventorsMladen Trkovnik, Zrinka Ivezić
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Abstract
The present invention relates to novel hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the general formulae I, II, III and IV: wherein R1=R2=4-hydroxycoumarin; R1=R2=4,7-dihydroxycoumarin; R1=R2=4,5,7-trihydroxycoumarin; R1=4-hydroxycoumarin, R2=—CH(OH)CH3. An object of the invention are also processes for the preparation of hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids, and the antiviral action thereof. Novel hydroxy and polyhydroxy derivatives of coumarin according to the present invention exhibit antiviral action against HIV-1 virus.
Claims10
Hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the formulae I, II, III and IV:
- wherein
- R1=R2=4-hydroxycoumarin;
- R1=R24,7-dihydroxycoumarin;
- R1=R2=4,5,7-trihydroxycomarin;
- R1=4-hydroxycoumarin, R2=—CH(OH)CH3.
Hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the formulae I, II, III and IV, characterized in that they exhibit an antiviral action against HIV-1 virus.
Dependencies are inferred from the claim text.