Protein ingredient for carrying lipophilic nutrients
AssigneeNorth Carolina State University
InventorsHarold E. Swaisgood, Qiwu Wang, Jonathan C. Allen
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Abstract
The present invention provides compositions comprising complexes of β-lactoglobulin with particular lipophilic nutrients, in particular vitamin E and vitamin K1. Preferably, bioselective absorption is employed to isolate β-Lg for use as a carrier protein. Also provided are food compositions and topical compositions comprising complexes of β-lactoglobulin and a lipophilic nutrient.
Claims30
A food composition comprising a food additive comprising a preformed complex comprising β-lactoglobulin and a lipophilic nutrient selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K1, cholesterol, and conjugated linoleic acid;
- wherein said β-lactoglobulin Is purified by at least 80% by bioselective absorption to an immobilized affinity ligand;
- and further wherein the solubility of said lipophilic nutrient in aqueous solutions is enhanced by complex formation with said purified β-lactoglobulin.
A dietary supplement comprising a preformed complex comprising β-lactoglobulin and a lipophilic nutrient selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K1, cholesterol, and conjugated linoleic acid;
- wherein said β-lactoglobulin is purified by at least 80% by bioselective absorption to an immobilized affinity ligand;
- and further wherein the solubility of said lipophilic nutrient in aqueous solutions is enhanced by complex formation with said purified P-lactoglobulin.
A method of manufacturing a food composition comprising β-lactoglobulin and a lipophilic nutrient, comprising the steps of:
- (a) purifying β-lactoglobulin by at least about 80% by bioselective absorption to an immobilized affinity ligand;
- (b) forming a preformed complex between the purified β-lactoglobulin of step a and a lipophilic nutrient selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K1, cholesterol, and conjugated linoleic acid, wherein the solubility of said lipophilic nutrient in aqueous solutions is enhanced by complex formation with said purified β-lactoglobulin;
- and
- (c) manufacturing a food composition comprising the preformed complex formed between the isolated β-lactoglobulin and the lipophilic nutrient of step b.
A food composition comprising a food additive comprising a preformed complex comprising β-lactoglobulin and a lipophilic nutrient selected from the group consisting of cholesterol, vitamin K1, vitamin D2, and vitamin D3;
- wherein said β-lactoglobulin is purified by at least 80% by bioselective absorption to an immobilized affinity ligand:
- and further wherein the solubility of said lipophilic nutrient in aqueous solutions is enhanced by complex formation with said purified β-lactoglobulin.
A method of manufacturing a food composition comprising β-lactoglobulin and a lipophilic nutrient, comprising the steps of:
- (a) purifying β-lactoglobulin by at least 80% by bioselective absorption to an immobilized affinity ligand;
- (b) forming a preformed complex between the purified β-lactoglobulin of step a and a lipophilic nutrient selected from the group consisting of cholesterol, vitamin K1, D2, and D3;
- and
- (c) manufacturing a food composition comprising the preformed complex formed between the isolated β-lactoglobulin and the lipophilic nutrient of step b.
A topical composition comprising a preformed complex comprising β-lactoglobulin and a lipophilic nutrient selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K1, cholesterol, and conjugated linoleic acid in a topical carrier;
- wherein said β-lactoglobulin is purified by at least 80% by bioselective absorption to an immobilized affinity ligand;
- and further wherein the solubility of said lipophilic nutrient in aqueous solutions is enhanced by complex formation with said purified β-lactoglobulin.
Dependencies are inferred from the claim text.