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US 6,290,967 B1Granted
Stabilizers for lyophilized vaccines
AssigneeMerck & Co., Inc.
InventorsDavid B. Volkin, Su-Pi Sheu, Carl J. Burke
Life of this patent
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Abstract
Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0.
Claims6
A vaccine comprising:
- (a) at least one attenuated virus, wherein said virus includes rubella virus and:
- (b) the following components, at the indicated final concentrations:
- (i) hydrolyzed gelatin, 28.94 g/L;
- (ii) sorbitol, 58.94 g/L;
- (iii) phosphate, 10.59 g/L;
- (iv) NaCl, 4.92 g/L;
- (v) sucrose, 43.74 g/L;
- (vi) bicarbonate, 0.92 g/L;
- (vi) glucose, 0.66 g/L;
- (vii) HSA, 0.62 g/L;
- (viii) citrate, 2.53 g/L.
8 more elements
Dependencies are inferred from the claim text.