Cancer treatment
AssigneeThe Procter & Gamble Company
InventorJames Berger Camden
Life of this patent
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Abstract
This invention is a method of treating cancer, including carcinomas and sarcomas, through the administration of a pharmaceutical composition containing an arylaldehyde 5-oxo-1,2,4-triazine hydrazide derivative. The arylaldehyde 5-oxo-1,2,4-triazine hydrazide derivative is selected from the group consisting of those with the formula: wherein R and R1 are independently selected from the group consisting of hydrogen and alkyl wherein the alkyl group has up to 7 carbon atoms; or a pharmaceutical salt thereof; a prodrug thereof; a metabolite thereof; and mixtures thereof. Pharmaceutical compositions comprising these compounds and their use in various treatment methods are claimed. The compounds can be used in conjunction with other chemotherapeutic agents and potentiators.
Claims37
A method of treating cancer comprising administering to a patient in need thereof a therapeutically effective amount of a composition comprising a compound having the formula:
- wherein R and R1 are independently selected from the group consisting of hydrogen and alkyl
- wherein the alkyl group has up to 7 carbon atoms;
- or a pharmaceutical salt thereof;
- a prodrug thereof;
- a metabolite thereof;
- or mixtures thereof.
A pharmaceutical composition comprising a therapeutically effective amount of a composition comprising a compound having the formula:
- wherein R and R1 are independently selected from the group consisting of hydrogen and alkyl
- wherein the alkyl group has up to 7 carbon atoms;
- or a pharmaceutical salt thereof;
- a prodrug thereof;
- a metabolite thereof;
- or mixtures thereof.
A method of treating cancer comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula:
- wherein R and R1 are independently selected from the group consisting of hydrogen and alkyl
- wherein the alkyl group has up to 7 carbon atoms;
- or a pharmaceutical salt thereof;
- a prodrug thereof;
- a metabolite thereof;
- or mixtures thereof;
- in a combination therapy with a safe and effective amount of a potentiator or a chemotherapeutic agent.
A liposome composition comprising a compound having the formula:
- wherein R and R1 are independently selected from the group consisting of hydrogen and alkyl
- wherein the alkyl group has up to 7 carbon atoms;
- or a pharmaceutical salt thereof;
- a prodrug thereof;
- a metabolite thereof;
- or mixtures thereof.
A pharmaceutical composition comprising the hydrochloride salt of a compound having the formula:
- wherein R and R1 are hydrogen, or R is methyl and R1 is hydrogen.
Dependencies are inferred from the claim text.