Medicament excipient particles for tissue-specific application of a medicament
AssigneeDSS Drug Delivery Service Gesellschaft zur Forderung der Foshung In Phamazeutischer Technologi und Biopharmazie mbH
InventorsRanier H. Müller, Martin Lück, Jörg Kreuter
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Abstract
The invention relates to medicament excipient particles which are suitable for tissue-specific application of a medicament, especially to the central nervous system (CNS). The invention particles can be loaded with or be free pf the active substance. At least one detection protein is bonded to the particle surface or alternatively, the particle surface is modified in such a way that a detection protein bonds with it on contact.
Claims55
Drug carrier particles, in active substance-loaded or active substance-free form, comprising carrier particles having at least one recognition protein or at least a receptor-recognizing molecule part of a recognition protein covalently bound ex-vivo to reactive surface groups present on the carrier particles.
Drug carrier particles, in active substance-loaded or active substance-free form, comprising carrier particles having at least one recognition protein or at least a receptor-recognizing molecule part of a recognition protein bound to a surface of the carrier particles ex-vivo by preferential adsorption, wherein the surface of the carrier particles having been chemically modified before the preferential adsorption by introducing functional groups or the surface properties changed by physical treatment with plasma.
A drug comprising:
- at least one drug;
- and
- carrier particles having at least one recognition protein or at least a receptor-recognizing molecule part of the recognition protein covalently bound ex-vivo to reactive surface groups present on the carrier particles.
A drug comprising:
- at least one drug;
- and
- carrier particles having at least one recognition protein or at least a receptor-recognizing molecule part of a recognition protein bound to a surface of the carrier particles ex-vivo by preferential adsorption, and wherein the surface of the carrier particles having been chemically modified before the preferential adsorption by introducing functional groups or the properties changed by physical treatment with plasma.
A method of making a drug comprising:
- combining at least one drug with carrier particles having at least one recognition protein or at least a receptor-recognizing molecule part of a recognition protein covalently bound ex-vivo to reactive surface groups on the carrier particles.
A method of making a drug comprising:
- combining at least one drug with carrier particles having at least one recognition protein or at least a receptor-recognizing molecule part of a recognition protein bound to the carrier particles ex-vivo by preferential adsorption, and wherein the surface of the carrier particles having been chemically modified before the preferential adsorption by introducing functional groups or the properties changed by physical treatment with plasma.
A method for making drugs comprising at least one drug and carrier particles, the method comprising:
- covalently bonding recognition proteins or receptor-recognizing molecule parts of recognition proteins to reactive surface groups of carrier particles ex-vivo.
A method for making drugs comprising at least one drug and carrier particles, the method comprising:
- bonding recognition proteins or receptor-recognizing molecule parts of recognition proteins to carrier particles ex-vivo using preferential adsorption in which a surface of the carrier particles has been chemically modified before the preferential adsorption by introducing functional groups or properties changed by physical treatment with plasma.
Dependencies are inferred from the claim text.