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AssigneeUniversity of Georgia Research Foundation, Inc.
InventorsSteven E. Poet, Branson W. Ritchie, Frank D. Niagro, Phil D. Lukert
Estimating the term…
Vaccine compositions which are protective against circovirus infections, including porcine circovirus and psittacine beak and feather disease virus, in animals, comprising a nucleic acid vector comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid encoding an animal circovirus polypeptide, wherein the nucleic acid lacks a viral origin of replication are disclosed. Nucleic acid vectors for the transient expression of one or more circovirus polypeptides in a eukaryotic cell comprising a nucleic acid vector comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to the nucleic acids of the invention are described. Methods of preventing a circovirus-associated disease in an animal comprising administering to the animal a nucleic acid vector comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid encoding an animal circovirus polypeptide, wherein the nucleic acid lacks a viral origin of replication are also described. Methods of preventing a circovirus-associated disease in an animal comprising administering to the animal an immunogenic amount of one or more animal circovirus polypeptides are also described. Also disclosed are nucleic acid and polypeptide sequences useful in the vaccine compositions and methods of the invention.
An isolated nucleic acid comprising a nucleic acid having a nucleotide sequence with 90% or greater homology to a sequence selected from the group consisting of:
A nucleic acid sequence comprising SEQ ID NO:6.
A nucleic acid vector for the expression of a circovirus polypeptide comprising a heterologous promoter functionally linked to a nucleic acid encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:
A nucleic acid vector for the expression of one or more circovirus polypeptides in a eukaryotic cell comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid with 90% or greater homology to at least one sequence selected from the group consisting of:
A nucleic acid vector for the expression of one or more circovirus polypeptides in a eukaryotic cell comprising a eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid sequence encoding one or more polypeptides with an amino acid sequence or sequences selected from the group consisting of:
Dependencies are inferred from the claim text.