Human parvovirus B19 proteins and virus-like particles, their production and their use in diagnostic assays and vaccines
AssigneeRijksuniversiteit te Leiden
InventorCaroline Sarah Brown
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Abstract
The invention relates to the coat proteins VP1 and VP2 of the human parvovirus B19 and virus-like particles consisting of VP2 or of VP1 and VP2. The invention further comprises genetic information in the form of recombinant expression vectors which contain the genes coding for said proteins, and organisms which through genetic manipulation using such vectors have acquired the ability to produce such proteins and/or particles. The invention further comprises uses of such proteins and virus-like particles for diagnostics or vaccination.
Claims13
Spodoptera frugiperda cells which by means of a baculovirus expression vector system have been provided with the genetic information which is necessary for expression of VP1 capsid protein of the human parvovirus B19.
Recombinant baculovirus expression vector, equipped with the genetic information which is necessary for expression of VP1 caspid protein of the human parvovirus B19 in Spodoptera frugiperda cells.
Recombinant baculovirus, equipped with the genetic information which is necessary for expression of VP1 caspid protein of the human parvovirus B19 in Spodoptera frugiperda cells.
Recombinant baculovirus AcB19VP1L.
Spodoptera frugiperda cells which by means so a baculovirus expression vector system nave been equipped with the genetic information that is necessary for expression of VP1 and VP2 capsid proteins of the human parvovirus B19.
Recombinant baculovirus expression vector, equipped with the genetic information which is necessary for expression of VP1 and VP2 capsid proteins of the human parvovirus B19 in Spodoptera frugiperda cells.
Recombinant baculovirus, equipped with the genetic information that is necessary for expression of VP1 and VP2 capsid protein of the human parvovirus B19 in Spodoptera frugiperda cells.
Dependencies are inferred from the claim text.