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US 6,287,792 B1Granted
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
AssigneeThe Regents of the University of California
InventorsWilliam M. Pardridge, Ruben J. Boado
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Abstract
A composition for delivering an agent to cells in vitro or to tissues or organs in vivo. The composition comprises either avidin or an avidin fusion protein bonded to a biotinylated agent to form an avidin-biotin-agent complex. A method is further provided for delivering an agent to cells using the avidin-biotin-agent complex which involves administering the complex to an individual subject. The avidin-biotin-agent complex is used in therapeutic and diagnostic methods.
Claims4
A composition for delivery of an agent to cells, said composition consisting of:
- a transport vector comprising an avidin moiety;
- at least one monobiotinylated agent bonded to said avidin moiety via an avidin-biotin linkage to provide an avidin-biotin-agent complex;
- and
- a pharmaceutically acceptable carrier.
1 more element
Dependencies are inferred from the claim text.