Topical nitric oxide donor compositions
AssigneeMeri Charmyne Russell
InventorMeri Charmyne Russell
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Abstract
Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID mixed in a lipid-based carrier are described. The application of such combinations to the affected areas, e.g., the hoofs and surrounding tissues, of an equine afflicted with laminitis provides relief from the debilitating effects of this painful, often life-threatening condition.
Claims19
A topical composition, comprising a fast acting nitric oxide (NO) donor and L-arginine (L-Arg) dispersed in a lipid-based carrier.
A tropical composition, comprising at least one fast acting nitric oxide (NO) donor, L-Arg and at least one NSAID dispersed in a lipid-based carrier comprising at least one membrane forming lipid, at least one first biocompatible aliphatic organic solvent comprising 8-50 carbon atoms, at least one second hydroxyl group containing aliphatic organic solvent comprising 1-7 carbon atoms and at least one surfactant.
A process for the preparation of a combination, comprising:
- (a) combining a first mixture comprising at least one alcoholic solvent, at least one fast acting nitric oxide (NO) donor, at least one sustained acting NO donor and at least one NSAID with a second mixture comprising at least one membrane forming lipid and at least one biocompatible organic solvent;
- and
- (b) admixing to the resulting mixture of step (a) an amount of a third mixture comprising water and a surfactant effective to provide a combination having a creamy texture.
Dependencies are inferred from the claim text.