Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles
AssigneeShire Laboratories, Inc.
InventorsBeth A. Burnside, Rong-Kun Chang, Xiaodi Guo
Life of this patent
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Abstract
A pharmaceutical composition comprising at least one pharmaceutically active agent that is pH dependent, at least one non-pH dependent sustained release agent, and at least one pH dependent agent that increases the dissolution rate of the at least one pharmaceutically active agent at a pH in excess of 5.5. Such compositions have minimized pH-dependent dissolution profiles or pH-independent dissolution profiles.
Claims30
A pharmaceutical composition, comprising:
- (a) at least one pharmaceutically active agent that is pH dependent:
- (b) at least one non-pH dependent sustained release agent;
- and
- (c) at least one pH dependent agent that increases the rate of release of said at least one pharmaceutically active agent from the tablet at a pH in excess of 5.5.
The composition of claim wherein said pH-dependent agent that increase the rate of release of the at least one pharmaceutically active agent from the tablet at a pH in excess of 5.5 is an agent that maintains an acidic microenvironment in the composition.
Dependencies are inferred from the claim text.