Hemofiltration systems, methods, and devices used to treat inflammatory mediator related disease

A hemofiltration system to treat an inflammatory mediator related disease such as sepsis and septic shock in a mammal comprising:

• a blood pump to pump a blood stream from said mammal;
• a first tubing to transfer said blood stream from said mammal to said blood pump;
• a hemofilter operable to remove ultrafiltrate from said blood stream extracted from said mammal and to create a filtered blood stream and an ultrafiltrate stream;
• a second tubing to transfer said blood stream from said blood pump to said hemofilter;
• a third tubing to transfer said filtered blood stream from said hemofilter to a three-way joint;
• an adsorptive device containing at least one adsorbent material operable to receive said ultrafiltrate stream from said hemofilter and to remove inflammatory mediators therefrom to create a post adsorption ultrafiltrate stream;
• a fourth tubing to transfer said ultrafiltrate stream from said hemofilter to said adsorptive device;
• means for selectively combining said post adsorption ultrafiltrate stream with said filtered blood stream along with returning said combined stream to said mammal to treat said inflammatory mediator related disease including a fifth tubing to transfer said post adsorption ultrafiltrate to a three-way stop cock;
• a sixth tubing to transfer said post adsorptive ultrafiltrate stream from said three-way stop cock to said three-way joint whereby selected portions of said post adsorption ultrafiltrate and said filtered blood form a combined stream;
• a seventh tubing to transfer said combined stream from said three-way joint to said mammal,
• an eighth tubing to transfer any of said post adsorption ultrafiltrate stream which is not returned to said mammal from said three-way stop cock to a waste reservoir;
• at least one ultrafiltrate pump operably coupled with said adsorptive device to assist with transferring said post adsorptive ultrafiltrate stream from said adsorptive device;
• and
• at lease one ultrafiltrate waste pump operably coupled with said three-way stop cock to assist with transferring any of said post adsorption ultrafiltrate stream which is not returned to said mammal to said waste reservoir through said eighth tubing.