Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring
AssigneeCephalon, Inc.
InventorsRichard W. Scott, Andrew G. Reaume, Karen Dorfman
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Abstract
This invention discloses a gene-targeted non-human mammal and generational offspring with respect to the gene encoding a mutant protein product of a mutated presenilin 1 gene (PS-1); more specifically, a gene-targeted mouse with respect to the gene sequence encoding the mutant protein product of PS-1 which has been mutated to contain the human P264L mutation. Methods for screening chemical compounds using such mammals are also disclosed.
Claims10
A gene-targeted mouse heterozygous for human presenilin-1 (PS-1) mutation, said mouse comprising, in its genome, a DNA sequence encoding a functionally active PS-1 protein comprising the human P264L mutation, wherein said PS-1 protein is expressed, and wherein the Aβ42 protein level is elevated relative to the Aβ42 protein level in a wild-type mouse.
A gene-targeted mouse homozygous for human presenilin-1 (PS-1) mutation, said mouse comprising, in its genome, a DNA sequence encoding a functionally active PS-1 protein comprising the human P264L mutation, wherein said PS-1 protein is expressed, and wherein the Aβ42 protein level is elevated relative to the Aβ42 protein level in a wild-type mouse.
Dependencies are inferred from the claim text.