TFPX synthesis
OwnerWilliam R. Dolbier, Jr., Xiao X. Rong +1inventors
InventorsWilliam R. Dolbier, Jr., Xiao X. Rong, Walter E. Stalzer
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Abstract
A method of making TFPX using an SN2 type nucleophilic displacement reaction. The method includes reacting a nucleophilic fluorine molecule with a nonfluorinated-tetrahalo-p-xylene molecule. Exemplary nucleophilic fluorine molecules include, but are not limited to, CsF, KF, NaF and LiF. The nonfluorinated-tetrahalo-p-xylene molecules may include, α,α,α′,α′-tetrachloro-p-xylene, α,α,α′,α′-tetrabromo-p-xylene or α,α,α′,α′-tetraiodo-p-xylene. The reaction may be carried out in an open or closed container. Furthermore, the reaction may be carried out in the presence of a phase transfer catalyst. In certain embodiments, the reaction is carried in a substantially solvent-free environment.
Claims25
A method of synthesizing TFPX, the method comprising the steps of:
- reacting a nucleophilic fluorine molecule comprising a fluoride of a Group IA or Group IIA metal with a nonfluorinated tetrahalo-p-xylene molecule to synthesize the TFPX via an SN2-type nucleophilic displacement reaction in a substantially solvent-free environment at a temperature of at least about 180° C., and wherein the reacting step is performed with a molar ratio of the nucleophilic fluorine molecule to the nonfluorinated tetrahalo-p-xylene compound of about 4 to 1.
A method of synthesizing TFPX, the method comprising the step of:
- reacting a nucleophilic fluorine molecule comprising a fluoride of a Group IA or Group IIA metal with TCPX to synthesize the TFPX via an SN2-type nucleophilic displacement reaction at a temperature of at least about 180° C., and wherein the reacting step is performed with a molar ratio of the nucleophilic fluorine molecule to the nonfluorinated tetrahalo-p-xlene compound of at least about 4 to 1.
A method of synthesizing TFPX, the method comprising the steps of:
- reacting a potassium fluoride molecule with TCPX to synthesize the TFPX via an SN2-type nucleophilic displacement reaction at a temperature of at least about 280° C., and wherein the reacting step is performed with a molar ratio of the nucleophilic fluorine molecule to the nonfluorinated tetrahalo-p-xylene compound of about 8 to 1.
Dependencies are inferred from the claim text.