Back to results
US 6,284,923 B1Granted
Substituted benzene compounds as antiproliferative and cholesterol lowering action
AssigneeTularik Inc.
InventorsJulio Cesar Medina, David Louis Clark, John A. Flygare, Terry J. Rosen, Bei Shan
Life of this patent
Estimating the term…
Abstract
The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general Formula I:
Claims16
A compound having the formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- n is 2;
- R1 is a member selected from the group consisting of hydrogen, (C1-C6) alkyl, halogen, OCF3, CF3, NO2, CN, and CO2—R8;
- R2 is a member selected from the group consisting of NO2, CN, CO2—R8 and SO2—R8;
- R3 is a member selected from the group consisting of halogen and OCF3;
- R4 is a member selected from the group consisting of hydrogen, halogen, OCF3, CF3, NO2, CN, and CO2—R8;
- R5 is a member selected from the group consisting of hydrogen, (C1-C6) alkyl, halogen, OCF3, CF3, NO2, CN, and CO2—R8;
- Y is N(R9);
- wherein R6 and R7 are each independently selected from the group consisting of hydrogen, (C1-C6) alkyl and (C2-C6) heteroalkyl;
- R8 is selected from the group consisting of (C1-C6) alkyl and (C2-C6) heteroalkyl;
- and R9 is selected from the group consisting of hydrogen, substituted or unsubstituted (C1-C10)alkyl, substituted or unsubstituted (C3-C6)alkenyl, subsituted or unsubstituted (C2-C6)heteroalkyl, substituted or unsubstituted (C3-C6)heteroalkenyl, substituted or unsubstituted (C3-C6)alkynyl, substituted or unsubstituted (C3-C8)cycloalkyl;
- and
- Ar is a substituted or unsubstituted phenyl group,
- wherein said substituents are independently selected from the group consisting of OH, halogen, NH2, NH(C1-C6)alkyl, N((C1-C6)alkyl)2, (C1-C6) alkyl, and (C1-C6)alkoxy.
11 more elements
Dependencies are inferred from the claim text.