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US 6,284,914 B1Granted
Highly water-soluble metalloproteinase inhibitors
AssigneeFuji Yakuhin Kogyo Kabushiki Kaisha
InventorsJunko Fujisawa, Eiko Suda, Katsuhiro Igeta, Tadanori Morikawa, Tetsunori Fujisawa, Shinjiro Odake, Yasuo Morita, Tomoko Hongo, Hajime Ito
Life of this patent
Estimating the term…
Abstract
New compounds of general formulae (III), (IV) and (V).
Claims3
Compounds of the general formula (III)
- wherein,
- R3 is a hydrogen atom, or a (C1-C6)alkyl, aryl or aryl(C1-C6)alkylene group,
- R4 is a hydrogen atom, or a (C1-C6)alkyl, aryl, aryl(C1-C6)alkylene or p-methoxyphenyl group,
- D is a hydrogen atom, a hydroxyl, protected phosphoric acid, protected diphosphonomethine, protected dicarboxymethine, nitro, amino, protected guanido, protected guanidomethylene, cyano, aminomethylene or protected amidino group, —Y—C″ or C″ group, wherein
- Y is a (C1-C6)alkylene group, an oxygen atom, an imino group, or a (C1-C6)alkyleneimino group,
- C″ is a sulfonic, phosphonic acid, amidino, (C1-C6)acyl, acylimidoyl, diphosphonomethine or dicarboxymethine group, with the provisio that at least one of R3, R4 and D is not a hydrogen atom and that when D is a hydroxyl group and either R3 or R4 is a hydrogen atom, neither R3 nor R4 is an ethyl or an n-propyl group.
3 more elements
Compounds of the general formula (IV)
- wherein,
- R1 is a hydrogen atom, or a hydroxyl, aryl(C1-C6)alkylene or —A—SOn—B group
- wherein A is a (C1-C6)alkylene group,
- B is a (C1-C6)alkyl, (C1-C6)acyl, aryl or heterocycle group, and
- n is 0, 1 or 2;
- R2 is a hydrogen atom, or a (C1-C4)alkyl, (C1-C6)alkyloxy or (C1-C6)alkylthio group;
- R3 is a hydrogen atom, or a (C1-C6)alkyl, aryl or aryl(C1-C6)alkylene group;
- R4 is a hydrogen atom, or a (C1-C6)alkyl, aryl, aryl(C1-C6)alkylene or p-methoxyphenyl group;
- R7 is (C1-C6)alkyl, benzyl, substituted benzyl, phenacyl or 2,2,2-trichloroethyl group;
- D is a hydrogen atom, a hydroxyl, protected phosphoric acid, protected diphosphonomethine, protected dicarboxymethine, nitro, amino, protected guanido, protected guanidomethylene, cyano, aminomethylene or protected amidino group, —Y—C″ or C″ group, wherein
- Y is a (C1-C6)alkylene group, an oxygen atom, an imino group, or a (C1-C6)alkyleneimino group,
- C″ is a sulfonic, phosphonic acid, amidino, (C1-C6)acyl, acylimidoyl, diphosphonomethine or dicarboxymethine group,
- with the proviso that when D is a hydroxyl group, R2 is an iso-propyl group and either R3 or R4 is a hydrogen atom, neither R3 nor R4 is a methyl group.
10 more elements
Compounds of the general formula (V)
- wherein
- R2 is a hydrogen atom, or a (C1-C4)alkyl, (C1-C6)alkyloxy or (C1-C6)alkylthio group;
- R3 is a hydrogen atom, or a (C1-C6)alkyl, aryl or aryl(C1-C6)alkylene group,
- R4 is a hydrogen atom, or a (C1-C6)alkyl, aryl, aryl(C1-C6)alkylene or p-methoxyphenyl group,
- D is a hydrogen atom, a hydroxyl, protected phosphoric acid, protected diphosphonomethine, protected dicarboxymethine, nitro, amino, protected guanido, protected guanidomethylene, cyano, aminomethylene or protected amidino group, —Y—C″ or C″ group, wherein
- Y is a (C1-C6)alkylene group, an oxygen atom, an imino group, or a (C1-C6)alkyleneimino group,
- C″ is a sulfonic, phosphonic acid, amidino, acylimidoyl, diphosphonomethine or dicarboxymethine group.
4 more elements
Dependencies are inferred from the claim text.