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US 6,284,903 B1Granted
Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorJacob Bar-Tana
Life of this patent
Estimating the term…
Abstract
The present invention relates to a novel class of compounds for treating hyperlipidemia, obesity and impaired glucose tolerance/noninsulin dependent diabetes mellitus without adversely affecting energy metabolism, and pharmaceutical compositions comprising the aforementioned compounds for the treatment of obesity, hyperlipidemia and maturity-onset diabetes.
Claims10
A composition represented by the general fomula
- where R1-Reach independently repersents an unsubstituted hydrocarbyl or heteroclyl radical;
- where R3 and R6 independently represents hydrogen, hydroxyl, lower alkyl, chloro, bromo, cyano, nitro, lower alkoxy or triflouromethyl;
- Q represents a diradical consisting of a linear chain of 4 to 14 carbon atoms, one or more of which may be replaced by heteroatoms, said chain being optionally substituted by inert substituents and one or more of said carbon or heteroatom chain members optionally forming part of a ring structure, and where one or both of the carboxyl groups can be substituted by an in vitro hydrolyzable physiologically acceptable substituent.
A compound represented by the formula
- where n is an integer from 6 to 12, and their hydrolyzable functional derivatives.
Dependencies are inferred from the claim text.