Abeo-ergoline derivatives as 5HT1A ligands

A compound represented by formula I″:

• wherein
• R1 is a hydrogen, chlorine or bromine atom or a methyl, methylthio, hydroxy, cyano, nitro or carboxamido group;
• R2 is C1-C3 alkyl or an allyl group;
• R3 and R4 are independently a hydrogen atom, a linear or branched C1-C5 alkyl group, a linear or branched C3-C5 alkenyl group, a C5-C6 cycloalkyl C1-C3 alkyl group, a phenyl-C1-C3 alkyl, a phenyl-C3-C5 alkenyl or phenyl group:
• which groups are optionally substituted by C1-C3 alkyl, C1-C3 alkoxy, trifluoromethyl, hydroxy or amino group;
• or a group of the formula
• wherein
• R6 is a hydrogen atom or a C1-C3 alkyl group and R7 is a phenyl group or a substituted phenyl group as described above;
• between positions 9-10 represents a single or a double bond;
• R5 is a hydrogen, bromine, fluorine or iodine atom or a methoxy, cyano, carboxamido, nitro, methylthio or trifluoromethyl or a group of the formula NR8R9 wherein R8 and R9 are independently a hydrogen atom, or a C1-3 alkyl, acetyl, methanesulphonyl or trifluoroacetyl group;
• and
• R represents a hydrogen atom or a C1-5 linear or branched alkyl, methanesulphonyl or acetyl group or a group of the formula CONR8R9 wherein R8 and R9 are as defined above;
• or a pharmaceutically acceptable salt thereof.