Polymeric surface coatings
AssigneeBiccompatibles Limited
InventorsRoderick W. J. Bowers, Stephen A. Jones, Peter W. Stratford
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Abstract
A non-crosslinked biocompatible polymer is formed from a radical polymerisable ethylenically unsaturated zwitterionic monomer containing a sulpho-betaine zwitterionic group and a radical polymerisable ethylenically unsaturated comonomer containing a hydrophobic group selected from C6-24-alkyl, C1-24-fluoroalkyl and siloxane groups. Suitable copolymers are of N,N-dimethyl ammonium-N-propylsulphonate-N-ethyl methacrylate and dodecylmethacrylate. The polymer may be used to coat substrates to render them biocompatible, especially hemocompatible. The hydrophobic groups render the polymer particularly suitable for coating hydrophobic substrates.
Claims12
A non-crosslinked biocompatible polymer formed from an ethylenically unsaturated monomer consisting essentially of
- (a) a radical polymerisable ethylenically unsaturated zwitterionic monomer containing a zwitterionic group having formula (I):
- Y—B—X (I)
- wherein
- B is a straight or branched alkylene;
- Y is an ethylenically unsaturated polymerisable group
- wherein R is hydrogen or a C1-C4 alkyl group;
- A is —O— or —NR1— where R1 is hydrogen or a C1-C4 alkyl group;
- and
- X is a zwitterionic group IVB
- where the groups R6 are the same or different and each is hydrogen or C14 alkyl and d is 2 to 4;
- and
- (b) a comonomer of formula (VI)
- Y1—Q (VI)
- where Y1 is an ethylenically unsaturated polymerisable group
- where R14 is hydrogen or C1-C4 alkyl,
- A′ is —O— or NR15— where R15 is hydrogen or a C1-C4 alkyl group and
- Q is the hydrophobic group and is selected from the group consisting of C6-24-alkyl groups;
- with a molar ratio of zwitterionic monomer to comonomer in a range 10:90 to 50:50.
Dependencies are inferred from the claim text.