# US 6,284,805 B1 · Plastics container containing stabilized drug formulation

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- Number: US 6,284,805 B1
- Document ID: US6284805B1
- Status: Granted
- Kind: B1
- Application number: 09/433,158
- Filed: 1999-11-03
- Granted: 2001-09-04
- Earliest claimed: 1998-11-04
- Assignees: Darwin Discovery, Ltd.
- Inventors: Stephen Brown
- Web page: https://patentgrep.com/patent/US6284805B1

## CPC

- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61P 23/00: Anaesthetics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A plastics container containing a sterile aqueous solution of an acid addition salt of a 1-alkyl-N-(2,6-dimethylphenyl)-2-piperidinecaboxamide, wherein the solution is buffered.

## Claims

### Claim 1

A plastic container containing a sterile aqueous solution of an acid addition salt of a 1-alkyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide, wherein the solution is buffered to pH 3-6.

### Claim 2 (depends on 1)

The container according to claim 1, wherein the container is an ampoule or vial.

### Claim 3 (depends on 1)

The container according to claim 1, wherein the container is a bag.

### Claim 4 (depends on 1)

The container according to claim 1, wherein the material of the container is polypropylene.

### Claim 5 (depends on 1)

The container according to claim 1, wherein the salt is a hydrohalide.

### Claim 6 (depends on 5)

The container according to claim 5, wherein the salt is the hydrochloride.

### Claim 7 (depends on 1)

The container according to claim 1, wherein the carboxamide is bupivacaine or levobupivacaine.

### Claim 8 (depends on 1)

The container according to claim 1, wherein the solution comprises at least 0.75% w/v of the carboxanide.

### Claim 9 (depends on 1)

The container according to claim 1, wherein the solution is buffered to pH 3.5-5.

### Claim 10 (depends on 1)

The container according to claim 1, wherein the buffer is citrate.

### Claim 11 (depends on 2)

The container according to claim 2, wherein the material of the container is polypropylene.

### Claim 12 (depends on 3)

The container according to claim 3, wherein the material of the container is polypropylene.