# US 6,284,803 B1 · Solid dosage form with polymeric binder

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- Number: US 6,284,803 B1
- Document ID: US6284803B1
- Status: Granted
- Kind: B1
- Application number: 09/395,775
- Filed: 1999-09-14
- Granted: 2001-09-04
- Earliest claimed: 1998-09-24
- Assignees: BASF SE
- Inventors: Stephan Kothrade; Gunther Berndl; Helmut Meffert
- Web page: https://patentgrep.com/patent/US6284803B1

## CPC

- A61K 9/2027: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates}
- A61K 9/2095: {Tabletting processes}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention relates to a solid dosage form comprising at least one polymeric binder and at least one active ingredient and, where appropriate, conventional additives, wherein the polymeric binder consists of copolymerized units a) 15-83% by weight of at least one N-vinyllactam, b) 15-83% by weight of methyl methacrylate, c) 2-70% by weight of at least one other monomer and d) 0-9.9% by weight of at least one α,β-ethylenically unsaturated acid.

## Claims

### Claim 1

A solid dosage form comprising at least one polymeric binder, and at least one active ingredient wherein the polymeric binder consists essentially of copolymerization units of
a) 30-65% by weight of at least one N-vinyllactam of the formula I
in which n is 1,2, or 3,
b) 20-55% by weight of methyl methacrylate,
c) 15-50% by weight of at least one other monomer selected from vinyl esters of aliphatic C1-C22-carboxylic acids, esters of α, β-ethylenically unsaturated C3-C8-mono- and dicarboxylic acids wight C1-C8-alkanols, C1-C4-diols or di-(C1-C4-alkyamino-C1-C4-alkanols, amides, nitrites, and cyclic anhydrides of the carboxylic acids, and
d) 0-5% by weight of at least on α, β-ethylenically unsaturated acid selected from C3-C8-mono- and -dicarboxylic acids, noncyclic anhydrides of these carboxylic acids, monoesters of the C3-C8-dicarboxylic acids, α, β-ethylenically unsaturated sulfonic acids and the salts or quaternized products thereof.

### Claim 2 (depends on 1)

A solid dosage form as claimed in claim 1, wherein the N-vinyllactam is N-vinylpyrrolidone.

### Claim 3 (depends on 1)

A solid dosage form as claimed in claim 1, wherein the other monomers c) are vinyl esters of aliphatic C1-C22-carboxylic acids.

### Claim 4 (depends on 1)

A pharmaceutical composition, crop treatment composition, feed additive or dietary supplement comprising the dosage form of claim 1.