# US 6,284,802 B1 · Methods for regulating the condition of mammalian keratinous tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 6,284,802 B1 - Document ID: US6284802B1 - Status: Granted - Kind: B1 - Application number: 09/541,965 - Filed: 2000-04-04 - Granted: 2001-09-04 - Earliest claimed: 1999-04-19 - Assignees: The Procter & Gamble Company - Inventors: Donald Lynn Bissett; Elizabeth Ann Jewell-Motz - Web page: https://patentgrep.com/patent/US6284802B1 ## CPC - A61K 8/29: Titanium; Compounds thereof - A61K 8/34: Alcohols - A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain} - A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings - A61K 8/37: Esters of carboxylic acids - A61K 8/40: containing nitrogen (quinones containing nitrogen A61K8/355) - A61K 8/42: Amides - A61K 8/466: {containing sulfonic acid derivatives; Salts} - A61K 8/4926: {having six membered rings} - A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof - A61K 8/675: {Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde (tocopheryl nicotinate A61K8/678)} - A61Q 19/00: Preparations for care of the skin - A61Q 19/08: Anti-ageing preparations - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of farnesol; and b) a dermatologically-acceptable carrier for the farnesol. In additional embodiments, the above composition is suitable for thickening skin and preventing and/or retarding atrophy of mammalian skin, preventing and/or retarding the appearance of spider vessels and/or red blotchiness on mammalian skin, preventing and/or retarding the appearance of dark circles under the eye of a mammal, preventing and/or retarding sallowness of mammalian skin, preventing and/or retarding sagging of mammalian skin, softening and/or smoothing lips, hair and nails of a mammal, and preventing and/or relieving itch of mammalian skin. ## Claims ### Claim 1 A method of regulating the condition of mammalian keratinous tissue, said method comprising the step of topically applying to the keratinous tissue of a mammal in need of such regulation, a safe and effective amount of a composition comprising: a) a safe and effective amount of a keratinous tissue condition regulating agent consisting essentially of farnesol; and b) a dermatologically-acceptable carrier for the regulating agent. ### Claim 2 (depends on 1) The method of claim 1 wherein the composition comprises from about 0.001% to about 100%, by weight of the composition, of farnesol. ### Claim 3 (depends on 1) The method of claim 1 wherein said composition additionally comprises a safe and effective amount of a skin care active other than farnesol, selected from the group consisting of desquamatory actives, anti-acne actives, vitamin B3 compounds, retinoids, peptides, hydroxy acids, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, structuring agents, thickening agents, and combinations thereof. ### Claim 4 (depends on 3) The method of claim 3 wherein the desquamatory active is cetyl betaine; the vitamin B3 compound is selected from the group consisting of niacinamide, tocopherol nicotinate, and combinations thereof; the retinoid is retinyl propionate, the peptide is a pentapeptide or a derivative thereof; the hydroxy acid is salicylic acid, the anti-oxidant is selected from the group consisting of tocopherol, tocopherol esters, and combinations thereof; the anti-inflammatory agent is selected from the group consisting of bisabolol, phytosterol, and combinations thereof; the flavonoid is isoflavone, the conditioning agent is selected from the group consisting of panthenol, allantoin, and combinations thereof; and combinations thereof. ### Claim 5 A method of thickening the skin and/or preventing/retarding skin atrophy of a mammal, said method comprising the step of topically applying to the skin of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of farnesol; and b) a dermatologically-acceptable carrier for the farnesol. ### Claim 6 (depends on 5) The method of claim 5 wherein said composition additionally comprises a safe and effective amount of a skin care active other than farnesol, selected from the group consisting of desquamatory actives, anti-acne actives, vitamin B3 compounds, retinoids, peptides, hydroxy acids, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, structuring agents, thickening agents, and combinations thereof. ### Claim 7 (depends on 6) The method of claim 6 wherein the desquamatory active is cetyl betaine; the vitamin B3 compound is selected from the group consisting of niacinamide, tocopherol nicotinate, and combinations thereof; the retinoid is retinyl propionate, the peptide is a pentapeptide or a derivative thereof, the hydroxy acid is salicylic acid, the anti-oxidant is selected from the group consisting of tocopherol, tocopherol esters, and combinations thereof; the anti-inflammatory agent is selected from the group consisting of bisabolol, phytosterol, and combinations thereof; the flavonoid is isoflavone, the conditioning agent is selected from the group consisting of panthenol, allantoin, and combinations thereof; and combinations thereof. ### Claim 8 A method of preventing and/or retarding the appearance of spider vessels and/or red blotchiness on mammalian skin, said method comprising the step of topically applying to the skin of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of farnesol; and b) a dermatologically-acceptable carrier for the farnesol. ### Claim 9 (depends on 8) The method of claim 8 wherein said composition additionally comprises a safe and effective amount of a skin care active other than farnesol, selected from the group consisting of desquamatory actives, anti-acne actives, vitamin B3 compounds, retinoids, peptides, hydroxy acids, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, structuring agents, thickening agents, and combinations thereof. ### Claim 10 (depends on 9) The method of claim 9 wherein the desquamatory active is cetyl betaine; the vitamin B3 compound is selected from the group consisting of niacinamide, tocopherol nicotinate, and combinations thereof; the retinoid is retinyl propionate, the peptide is a pentapeptide or a derivative thereof, the hydroxy acid is salicylic acid, the anti-oxidant is selected from the group consisting of tocopherol, tocopherol esters, and combinations thereof; the anti-inflammatory agent is selected from the group consisting of bisabolol, phytosterol, and combinations thereof; the flavonoid is isoflavone, the conditioning agent is selected from the group consisting of panthenol, allantoin, and combinations thereof; and combinations thereof. ### Claim 11 A method of preventing and/or retarding the appearance of dark circles on the skin under the eye of a mammal, said method comprising the step of topically applying to the skin surrounding the eye of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of farnesol; and b) a dermatologically-acceptable carrier for the farnesol. ### Claim 12 (depends on 11) The method of claim 11 wherein said composition additionally comprises a safe and effective amount of a skin care active other than farnesol, selected from the group consisting of desquamatory actives, anti-acne actives, vitamin B3 compounds, retinoids, peptides, hydroxy acids, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, structuring agents, thickening agents, and combinations thereof. ### Claim 13 (depends on 12) The method of claim 12 wherein the desquamatory active is cetyl betaine; the vitamin B3 compound is selected from the group consisting of niacinamide, tocopherol nicotinate, and combinations thereof; the retinoid is retinyl propionate, the peptide is a pentapeptide or a derivative thereof, the hydroxy acid is salicylic acid, the anti-oxidant is selected from the group consisting of tocopherol, tocopherol esters, and combinations thereof; the anti-inflammatory agent is selected from the group consisting of bisabolol, phytosterol, and combinations thereof; the flavonoid is isoflavone, the conditioning agent is selected from the group consisting of panthenol, allantoin, and combinations thereof; and combinations thereof. ### Claim 14 A method of preventing and/or retarding sallowness of mammalian skin, said method comprising the step of topically applying to mammalian skin needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of farnesol; and b) a dermatologically-acceptable carrier for the farnesol. ### Claim 15 (depends on 14) The method of claim 14 wherein said composition additionally comprises a safe and effective amount of a skin care active other than farnesol, selected from the group consisting of desquamatory actives, anti-acne actives, vitamin B3 compounds, retinoids, peptides, hydroxy acids, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, structuring agents, thickening agents, and combinations thereof. ### Claim 16 (depends on 15) The method of claim 15 wherein the desquamatory active is cetyl betaine; the vitamin B3 compound is selected from the group consisting of niacinamide, tocopherol nicotinate, and combinations thereof; the retinoid is retinyl propionate, the peptide is a pentapeptide or a derivative thereof, the hydroxy acid is salicylic acid, the anti-oxidant is selected from the group consisting of tocopherol, tocopherol esters, and combinations thereof; the anti-inflammatory agent is selected from the group consisting of bisabolol, phytosterol, and combinations thereof; the flavonoid is isoflavone, the conditioning agent is selected from the group consisting of panthenol, allantoin, and combinations thereof; and combinations thereof. ### Claim 17 A method of preventing and/or retarding sagging of mammalian skin, said method comprising, the step of topically applying to the skin of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of farnesol; and b) a dermatologically-acceptable carrier for the farnesol. ### Claim 18 (depends on 17) The method of claim 17 wherein said composition additionally comprises a safe and effective amount of a skin care active other than farnesol, selected from the group consisting of desquamatory actives, anti-acne actives, vitamin B3 compounds, retinoids, peptides, hydroxy acids, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, structuring agents, thickening agents, and combinations thereof. ### Claim 19 (depends on 18) The method of claim 18 wherein the desquamatory active is cetyl betaine; the vitamin B3 compound is selected from the group consisting of niacinamide, tocopherol nicotinate, and combinations thereof; the retinoid is retinyl propionate, the peptide is a pentapeptide or a derivative thereof, the hydroxy acid is salicylic acid, the anti-oxidant is selected from the group consisting of tocopherol, tocopherol esters, and combinations thereof; the anti-inflammatory agent is selected from the group consisting of bisabolol, phytosterol, and combinations thereof; the flavonoid is isoflavone, the conditioning agent is selected from the group consisting of panthenol, allantoin, and combinations thereof; and combinations thereof. ### Claim 20 A method of softening and/or smoothing lips, hair and nails of a mammal, said method comprising the step of topically applying to the lips, hair, and nails of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of a softening/smoothing agent consisting essentially of farnesol; and b) a dermatologically-acceptable carrier for the softening/smoothing agent. ### Claim 21 (depends on 20) The method of claim 20 wherein said composition additionally comprises a safe and effective amount of a skin care active other than farnesol, selected from the group consisting of desquamatory actives, anti-acne actives, vitamin B3 compounds, retinoids, peptides, hydroxy acids, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, structuring agents, thickening agents, and combinations thereof. ### Claim 22 (depends on 21) The method of claim 21 wherein the desquamatory active is cetyl betaine; the vitamin B3 compound is selected from the group consisting of niacinamide, tocopherol nicotinate, and combinations thereof; the retinoid is retinyl propionate, the peptide is a pentapeptide or a derivative thereof, the hydroxy acid is salicylic acid, the anti-oxidant is selected from the group consisting of tocopherol, tocopherol esters, and combinations thereof; the anti-inflammatory agent is selected from the group consisting of bisabolol, phytosterol, and combinations thereof; the flavonoid is isoflavone, the conditioning agent is selected from the group consisting of panthenol, allantoin, and combinations thereof; and combinations thereof. ### Claim 23 A method of preventing and/or relieving itch of mammalian skin, said method comprising the step of topically applying to the skin of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of farnesol; and b) a dermatologically-acceptable carrier for the farnesol. ### Claim 24 (depends on 23) The method of claim 23 wherein said composition additionally comprises a safe and effective amount of a skin care active other than farnesol, selected from the group consisting of desquamatory actives, anti-acne actives, vitamin B3 compounds, retinoids, peptides, hydroxy acids, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, structuring agents, thickening agents, and combinations thereof. ### Claim 25 (depends on 24) The method of claim 24 wherein the desquamatory active is cetyl betaine; the vitamin B3 compound is selected from the group consisting of niacinamide, tocopherol nicotinate, and combinations thereof; the retinoid is retinyl propionate, the peptide is a pentapeptide or a derivative thereof, the hydroxy acid is salicylic acid, the anti-oxidant is selected from the group consisting of tocopherol, tocopherol esters, and combinations thereof; the anti-inflammatory agent is selected from the group consisting of bisabolol, phytosterol, and combinations thereof; the flavonoid is isoflavone, the conditioning agent is selected from the group consisting of panthenol, allantoin, and combinations thereof; and combinations thereof.