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US 6,284,798 B1Granted
Guanidine derivatives, methods of preparing them and their use as drugs
AssigneeCancer Research Ventures Limited
InventorsEberhard Amtmann, Norbert Frank, Gerhard Sauer, Gerhard Schilling
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Abstract
The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing compounds, of formula (I), wherein wherein x is —NH—NH—CH2R1 and R1 denotes C8 to C20 alkyl.
Claims6
A compound having the formula:
- wherein X denotes —NH—NH—CH2R1 and R1 denotes C8 to C20 -alkyl, either branched or unbranched;
- and optionally in the form of the individual optical isomers, mixtures of the individual isomers or racemates, tautomers and the corresponding acid addition salts with pharmaceutically acceptable acids.
A process for preparing a compound of the formula
- , wherein R1 represents C8 to C20 alkyl, either branched or unbranched, said process comprising a first step of reacting an aldehyde having the general formula R1CHO with an aminoguanidine, a second step of reducing the imine function resulting from the first step in the presence of a hydrogenation catalyst under elevated hydrogen pressure and isolating the reaction product, and optionally forming the corresponding acid addition salt with a pharmaceutically acceptable acid.
Dependencies are inferred from the claim text.