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US 6,284,795 B1Granted
Sulfonamide compounds and methods of treating atherosclerosis and restenosis
AssigneeWarner-Lambert Company
InventorsHelen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Karen Elaine Sexton
Life of this patent
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Abstract
The present invention provides compounds having the Formula I The present invention also provides methods of treating or preventing atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions comprising the compounds of Formula I.
Claims16
A compound of the Forrnula I
- wherein
- R1 is —(CH2)n-C3-C8 cycloalkyl, —(CH2)n-aryl or —(CH2)n-aryl substituted by 1 to 3 substituents which are —C1-C6 alkyl, —O—C1-C6 alkyl, —S—C1-C6 alkyl, —OH, —SH, —F, —CN, —Cl, —Br, —I, —CF3, —NO2, —CO2H, —CO2C1-C6 alkyl, —NH2, —NHC1-C6 alkyl, N(C1-C6alkyl)2, or —
- R2 is C1-C6 alkyl, aryl, aryl substituted by 1 to 3 substituents which are —C1-C6 alkyl, —O—C1-C6 alkyl, and —S—C1-C6 alkyl, —OH, —SH, —F, —CN, —Cl, —Br, —I, —CF3, —NO2, —CO2H, —CO2C1-C6 alkyl, —NH2, —NHC1-C6 alkyl, N(C1-C6alkyl)2, or
- —NH(O═C)—C1-C6 alkyl, or
- n is 0 to 4, and the pharmaceutically acceptable salts thereof.
2 more elements
A compound of the Formula I
- wherein
- R1 is —CH2 cyclohexyl;
- R2 is —C1-C6 alkyl, substituted phenyl, or —CH2-phenyl;
- salt thereof.
1 more element
Dependencies are inferred from the claim text.