US 6,284,787 B1 · Use of R-(+)-α-lipoic acid, R-(−)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae

Abstract

The invention relates to the use of R-(+)-α-lipoic acid, R-(−)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin B, vitamin C, NADH, NADPH and ubiquinone. The invention furthermore relates to the use of R-(+)-α-lipoic acid, R-(−)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.

Claims2

Dependent claims

A process for the treatment of sequelae and late complications of diabetes mellitus comprising administering to a patient an effective amount of pure R-(+)-α-lipoic acid, pure R-(−)-dihydrolipoic acid, amides, salts, metabolites or esters thereof.

Dependencies are inferred from the claim text.

Facts

Application

09/628,295Filed 28 Jul 2000 · division

Priority

DE 43 43 59321 Dec 1993

Granted

4 Sep 2001

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 31/385
Having sulfur as a ring hetero atom: having two or more sulfur atoms in the same ring
A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid
A61K 31/22
Of carboxylic acids: of acyclic acids, e.g. pravastatin
A61K 31/355
3,4-Dihydrobenzopyrans, e.g. chroman, catechin: tocopherols, e.g. vitamin E

Use of R-(+)-α-lipoic acid, R-(−)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae

Life of this patent

Use of R-(+)-α-lipoic acid, R-(−)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae

Life of this patent

Abstract

Claims2